30335-66-1

Basic information

• Product Name: 5-chloro-2-nitro-1-benzofuran
• CAS NO: 30335-66-1
• Molecular Formula: C₈H₄ClNO₃
• Molecular Weight: 197.5753
• Mol File: 30335-66-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 310.4°C at 760 mmHg
• Flash Point: 141.5°C
• Density: 1.518g/cm³
• Vapor Pressure: 0.0011mmHg at 25°C
• Refractive Index: 1.656
• CAS DataBase Reference: 5-chloro-2-nitro-1-benzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-nitro-1-benzofuran(30335-66-1)
• EPA Substance Registry System: 5-chloro-2-nitro-1-benzofuran(30335-66-1)

Safety Data

• Hazardous Substances Data: 30335-66-1(Hazardous Substances Data)

Upstream product

• 14268-23-6 potassium trinitromethanide 
• 6296-65-7 1-(5-chloro-2-hydroxyphenyl)-N,N,N-trimethylmethanaminium iodide 
• 635-93-8 5-chlorosalicyclaldehyde 
• 61131-68-8 5-chloro-2-hydroxy-β-nitrostyrene 

Relevant articles and documents

Palladium(0)-Catalyzed Dearomatization of 2-Nitrobenzofurans through Formal (3+2) Cycloadditions with Vinylcyclopropanes: A Straightforward Access to Cyclopenta[ b ]benzofurans

In the context of the palladium-catalyzed dearomatization of electron-poor arenes, we report herein that various 2-nitrobenzofurans efficiently undergo a dearomative (3+2) cycloaddition with vinylcyclopropanes. This new method gives access to a wide variety of cyclo-penta[ b ]benzofuran derivatives in a straightforward manner.

Asymmetric dearomatization of 2-nitrobenzofurans by organocatalyzed one-step Michael addition to access 3,3′-disubstituted oxindoles

An efficient enantioselective dearomatization of 2-nitrobenzofurans was realized via an organocatalyzed one-step Michael addition process. This method provides a facile strategy to access a range of structurally diverse 3,3′-disubstituted oxindoles, which feature an intriguing combination of two privileged motifs including 3-pyrrolyl-substituted-oxindoles and 2,3-dihydrobenzofurans substructures, in excellent results.

Facile synthesis of chiral [2,3]-fused hydrobenzofuran: Via asymmetric Cu(i)-catalyzed dearomative 1,3-dipolar cycloaddition

Intermolecular asymmetric dearomative 1,3-dipolar cycloaddition of 2-nitrobenzofurans with azomethine ylides was enabled by using a chiral Cu(i)/(S,Sp)-iPr-Phosferrox catalyst. As a result, a series of highly stereoselective chiral [2,3]-fused hydrobenzofurans possessing four contiguous stereogenic centers were obtained with good to high yields, diastereoselectivities and enantioselectivities. The reaction has broad substrate scope tolerating various functional groups.