6296-65-7

Basic information

• Product Name: (5-chloro-2-hydroxyphenyl)-N,N,N-trimethylmethanaminium
• CAS NO: 6296-65-7
• Molecular Formula: C₁₀H₁₅ClNO*I
• Molecular Weight: 200.6847
• Mol File: 6296-65-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (5-chloro-2-hydroxyphenyl)-N,N,N-trimethylmethanaminium(CAS DataBase Reference)
• NIST Chemistry Reference: (5-chloro-2-hydroxyphenyl)-N,N,N-trimethylmethanaminium(6296-65-7)
• EPA Substance Registry System: (5-chloro-2-hydroxyphenyl)-N,N,N-trimethylmethanaminium(6296-65-7)

Safety Data

• Hazardous Substances Data: 6296-65-7(Hazardous Substances Data)

Usage

General Description

(5-chloro-2-hydroxyphenyl)-N,N,N-trimethylmethanaminium, also known as chlorhexidine, is a chemical compound with antiseptic and disinfectant properties. It is commonly used in medical and dental settings as a topical antiseptic for skin and mucous membranes, as well as a disinfectant for medical equipment and surfaces. It is also used in mouthwashes, wound care products, and as a preservative in various cosmetic and personal care products. Chlorhexidine works by disrupting the cell membrane of bacteria and fungi, making it an effective antimicrobial agent. However, it should be used with caution, as prolonged or excessive exposure to chlorhexidine can cause adverse effects such as skin irritation and allergic reactions.

Upstream product

• 54828-00-1 4-chloro-2-(dimethylaminomethyl)phenol 
• 74-88-4 methyl iodide 

Downstream Products

• 30335-66-1 nitro-2 chloro-5 benzofuranne 
• 95062-48-9 4-chloro-1,2-quinodimethane 

Relevant articles and documents

Substituents on quinone methides strongly modulate formation and stability of their nucleophilic adducts

Electronic perturbation of quinone methides (QM) greatly influences their stability and in turn alters the kinetics and product profile of QM reaction with deoxynucleosides. Consistent with the electron-deficient nature of this reactive intermediate, electron-donating substituents are stabilizing and electron-withdrawing substituents are destabilizing. For example, a dC N3-QM adduct is made stable over the course of observation (7 days) by the presence of an electron-withdrawing ester group that inhibits QM regeneration. Conversely, a related adduct with an electron-donating methyl group is very labile and regenerates its QM with a half-life of approximately 5 h. The generality of these effects is demonstrated with a series of alternative quinone methide precursors (QMP) containing a variety of substituents attached at different positions with respect to the exocyclic methylene. The rates of nucleophilic addition to substituted QMs measured by laser flash photolysis similarly span 5 orders of magnitude with electron-rich species reacting most slowly and electron-deficient species reacting most quickly. The reversibility of QM reaction can now be predictably adjusted for any desired application.