4996-15-0

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 80, p. 599, 1958 DOI: 10.1021/ja01536a021

InChI:InChI=1/C9H5NO4/c11-9(12)5-4-7-2-1-3-8(6-7)10(13)14/h1-3,6H,(H,11,12)

Upstream product

• 35283-09-1 ethyl 3-(3-nitrophenyl)propynoate 
• 637-44-5 phenylpropyolic acid 
• 18193-72-1 2,3-dibromo-3-(3-nitro-phenyl)-propionic acid 
• 7515-22-2 methyl 3-(3-nitrophenyl)propiolate 
• 124-38-9 carbon dioxide 
• 3034-94-4 3-nitrophenylacetylene 
• 121-90-4 m-nitrobenzoic acid chloride 
• 80414-60-4 5-(3-nitro-phenyl)-pyrazolidin-3-one 
• 96869-84-0 methyl 3-(3-nitrophenyl)-3-oxo-2-(triphenylphosphoranylidene)propanoate 
• 100246-45-5 4,4-dichloro-5-(3-nitro-phenyl)-2,4-dihydro-pyrazol-3-one 

Downstream Products

• 34875-23-5 β-bromo-3-nitro-cis-cinnamic acid 
• 34875-23-5 β-bromo-3-nitro-trans-cinnamic acid 
• 90945-65-6 2-acetoxy-1-(3-nitrophenyl)ethanone 
• 1130489-33-6 1-benzyl-4-(3-nitrophenyl)-5-phenyl-1H-1,2,3-triazole 
• 154479-68-2 1-(3-nitro-phenyl)-pentane-1,4-dione 
• 1549706-51-5 diisopropyl ((3-nitrophenyl)ethynyl)phosphonate 
• 1313531-28-0 C₂₁H₁₉N₅O₅ 
• 1313531-26-8 C₁₈H₂₁N₅O₅ 
• 1313531-43-9 C₂₁H₁₉N₅O₅ 
• 1313531-41-7 C₁₈H₂₁N₅O₅ 
• 1313531-38-2 C₂₃H₂₃N₅O₅ 
• 83256-99-9 3-(3-nitrophenyl)-3-oxopropionic acid methyl ester 
• 7515-22-2 methyl 3-(3-nitrophenyl)propiolate 
• 3034-94-4 3-nitrophenylacetylene 

Relevant academic research and scientific papers

Oxidant- and additive-free simple synthesis of 1,1,2-triiodostyrenes by one-pot decaroboxylative iodination of propiolic acids

A metal- and oxidant-free facile synthesis of a range of 1,1,2-triiodostryrene derivatives has been developed which utilizes a simple decarboxylative triiodination of propiolic acids using molecular iodine and sodium acetate in a one-pot manner. Electron-

3 - Aryl methylacetylene acid and 3 - aryl methylacetylene ester preparation method of compound (by machine translation)

The invention relates to a 3 - aryl methylacetylene acid compound preparation method: formula (I) shown phenylacetylene compound with carbon dioxide under the action of alkali, in solvent dimethyl sulfoxide in 40 - 70 °C under reaction, as shown in formula (II) of the 3 - aryl methylacetylene acid compounds, more than normal pressure of the body reaction in water-free, oxygen-free inert atmosphere, the reaction route is as follows: Wherein R1 Selected from hydrogen, alkyl, alkoxy, phenyl, nitro or halogen. The invention further provides a 3 - aryl methylacetylene ester preparation method of compound: adopting the above-mentioned method of the formula (II) is shown in the 3 - aryl methylacetylene acid compound, then adding the halogenated hydrocarbon or tosylates, after the in-situ reaction of the formula (III) is shown in the 3 - aryl methylacetylene ester compound: Wherein R2 Is selected from alkyl, benzyl or allyl. The method of the invention does not need to transition metal or rare earth metal catalyst, normal pressure reaction, mild condition, pervasive good substrate. (by machine translation)

Protonation of 3-arylpropynoic acid derivatives in superacids

According to the 1H and 13C NMR data, 3-arylpropynoic acids and their esters XC6Hn-C≡C-CO2R (R = H, Me, Et) having electron-withdrawing substituents in the benzene ring (X = NO2, CN, COMe,

(Ethoxycarbonyliodomethyl)triphenylphosphonium Iodide: A Convenient Reagent for the Direct Synthesis of β-Substituted Propiolic Acids via the Corresponding Esters

Reaction between (ethoxycarbonyliodomethyl)triphenylphosphonium iodide, potassium carbonate, and various aromatic or aliphatic aldehydes in a liquid solid two phases system gives β-substituted propiolic esters.The corresponding acids are obtained in good yield by hydrolysis.