30341-94-7

Basic information

• Product Name: methyl (8beta,10xi)-6-ethylergoline-8-carboxylate
• CAS NO: 30341-94-7
• Molecular Formula: C₁₈H₂₂N₂O₂
• Molecular Weight: 298.3795
• Mol File: 30341-94-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 464.5°C at 760 mmHg
• Flash Point: 234.7°C
• Density: 1.197g/cm³
• Vapor Pressure: 8.32E-09mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: methyl (8beta,10xi)-6-ethylergoline-8-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (8beta,10xi)-6-ethylergoline-8-carboxylate(30341-94-7)
• EPA Substance Registry System: methyl (8beta,10xi)-6-ethylergoline-8-carboxylate(30341-94-7)

Safety Data

• Hazardous Substances Data: 30341-94-7(Hazardous Substances Data)

Upstream product

• 75-07-0 acetaldehyde 
• 30341-92-5 #rac-ergoline-8β-carboxylic acid methyl ester 
• 67-56-1 methanol 
• 30341-95-8 6-ethylergoline-8β-carboxylic acid 
• 80993-64-2 9-methyl 7-(2,2,2-trichloroethyl) (6aR,9R,10aR)-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-7,9(4H)-dicarboxylate 
• 3006-19-7 9,10-dihydrolysergic acid methyl ester 
• 5878-43-3 9,10-dihydrolysergic acid 
• 51260-62-9 D-6-cyano-8β-methoxycarbonylergoline 
• 30341-92-5 methyl (6aR,9R,10aR)-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxylate 
• 75-03-6 ethyl iodide 
• 74-96-4 ethyl bromide 

Downstream Products

• 74627-23-9 Toluene-4-sulfonic acid (6aR,9R,10aR)-7-ethyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinolin-9-ylmethyl ester 

Relevant articles and documents

Ergoline derivatives as highly potent and selective antagonists at the somatostatin sst1 receptor

Non-peptidic compounds containing the octahydro-indolo[4,3-fg]quinoline (ergoline) structural element have been optimized into derivatives with high affinity (pKd r sst1 > 9) and selectivity (>1000-fold for h sst1 over h sst2-h sst5) for the somatostatin sst1 receptor. In functional assays, these ergolines act as antagonists at human recombinant sst1 receptors. Pharmacokinetic studies in rodents reveal good oral bioavailability and brain penetration for some of these compounds.

EPIMERIZATION OF ESTERS OF STEREOISOMERIC 8-ERGOLINECARBOXYLIC ACIDS ON CARBON C(8)

Esters of 8β-ergolinecarboxylic acids, I-XI, exposed to strong bases, such as lithium diisopropylamide, in polar aprotic solvents gave enolates, which were decomposed by suitable proton donors to a mixture of epimers.This contained, apart from the starting 8β-esters, the corresponding 8α-esters, Ia-IVa and VIa-XIa (65-80percent) and Va (about 16percent).Exposure of 8α-ester XIIa to these conditions produced epimerization on C(8) (about 54percent) and, to a small extent, isomerization on C(10), affording ester I(c. 1percent) and Ia (c. 5percent).