303991-47-1

Basic information

• Product Name: 2-Bromo-N-o-tolylbenzamide
• Synonyms: 2-Bromo-N-(2-methylphenyl)benzamide;2-Bromo-N-o-tolylbenzamide;N-(2-Methylphenyl) 2-bromobenzamide
• CAS NO: 303991-47-1
• Molecular Formula: C₁₄H₁₂BrNO
• Molecular Weight: 275.12
• Product Categories: blocks;Bromides;Carboxes
• Mol File: 303991-47-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 317.8°Cat760mmHg
• Flash Point: 146°C
• Appearance: /
• Density: 1.445g/cm³
• Vapor Pressure: 0.000376mmHg at 25°C
• Refractive Index: 1.651
• Storage Temp.: 2-8°C
• PKA: 12.77±0.70(Predicted)
• CAS DataBase Reference: 2-Bromo-N-o-tolylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-N-o-tolylbenzamide(303991-47-1)
• EPA Substance Registry System: 2-Bromo-N-o-tolylbenzamide(303991-47-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 303991-47-1(Hazardous Substances Data)

Usage

General Description

2-Bromo-N-o-tolylbenzamide is an organic compound that belongs to the class of benzamides. It is also known as 2-Bromo-N-(o-tolyl)benzamide and has the chemical formula C14H12BrNO. With a molecular weight of 286.16 g/mol, this compound is commonly used for research and laboratory purposes as a building block for the synthesis of various pharmaceuticals and agrochemicals. It is a white to off-white solid with a melting point of 83-87°C and is primarily utilized as an intermediate in the production of other organic compounds. This chemical is also known for its potential application as an antimicrobial and antifungal agent, making it a valuable component in the development of new drugs and treatments.

InChI:InChI=1/C14H12BrNO/c1-10-6-2-5-9-13(10)16-14(17)11-7-3-4-8-12(11)15/h2-9H,1H3,(H,16,17)

Upstream product

• 7154-66-7 2-bromobenzoic acid chloride 
• 95-53-4 o-toluidine 
• 88-65-3 2-bromobenzoic-acid 

Downstream Products

• 72-44-6 methaqualone 
• 816418-36-7 4,5-dimethyl-5H-phenanthridin-6-one 
• 66087-58-9 2-Brom-N,2'-dimethylbenzanilid 
• 42970-52-5 (+/-)-5-(2-o-tolyl)phenanthridin-6(5H)-one 
• 33238-13-0 (Z)-3-benzylidene-2-(o-tolyl)isoindolin-1-one 

Relevant articles and documents

Synthesis and antibacterial activity of 5-methylphenanthridium derivatives as FtsZ inhibitors

5-Methylphenanthridium derivatives were designed, synthesized and evaluated for their in vitro antibacterial activity and cell division inhibitory activity against various Gram-positive and -negative bacteria. Among them, compounds 5A2, 5B1, 5B2, 5B3, 5C1 and 5C2 displayed the best on-target antibacterial activity with an MIC value of 4?μg/mL against B. subtilis ATCC9372 and S. pyogenes PS, showing over 2-fold better activity than sanguinarine. The SARs showed that the 5-methylphenanthridium derivatives with the alkyl side chains at the 2-postion, especially the straight alkyl side chains exerted better on-target antibacterial activity.

Direct arylation under catalysis of an oxime-derived palladacycle: Search for a phosphane-free method

A phosphane-free method for the direct arylation of benzothiazole by employing oxime-derived palladacycle 1 as a catalyst was developed. The new catalyst system can be used for 2-arylations by using aryl bromides and iodides. In addition, this method is especially suitable for the intramolecular direct coupling of bromo-and iodoamides, as well aschloroamides, to achieve a rapid synthesis of benzo[c]phenanthridine alkaloids. Direct arylation reactions under catalysis of an oxime-derived palladacycle were investigated. This phosphane-free method is applicable for the 2-arylation of benzothiazole and is especially suitable for the intramolecular direct coupling of bromo-and iodoamides, as well as chloroamides, to achieve rapid synthesis of benzo[c]phenanthridine alkaloids. Copyright