30411-81-5

Basic information

• Product Name: 1H-Benzimidazole,2-ethyl-5-methyl-(9CI)
• Synonyms: 1H-Benzimidazole,2-ethyl-5-methyl-(9CI);2-ETHYL-5-METHYLBENZIMIDAZOLE;1H-BenziMidazole, 2-ethyl-6-Methyl-;2-ethyl-6-methyl-1H-Benzimidazole;2-ethyl-5-methyl-1H-1,3-benzodiazole
• CAS NO: 30411-81-5
• Molecular Formula: C10H12N2
• Molecular Weight: 160.22
• Product Categories: BENZIMIDAZOLE
• Mol File: 30411-81-5.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 354.6°C at 760 mmHg
• Flash Point: 184.2°C
• Appearance: /
• Density: 1.111g/cm³
• Vapor Pressure: 6.77E-05mmHg at 25°C
• Refractive Index: 1.625
• CAS DataBase Reference: 1H-Benzimidazole,2-ethyl-5-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole,2-ethyl-5-methyl-(9CI)(30411-81-5)
• EPA Substance Registry System: 1H-Benzimidazole,2-ethyl-5-methyl-(9CI)(30411-81-5)

Safety Data

• Hazardous Substances Data: 30411-81-5(Hazardous Substances Data)

Usage

General Description

1H-Benzimidazole,2-ethyl-5-methyl-(9CI) is a chemical compound with the molecular formula C11H12N2. It is a derivative of benzimidazole, a heterocyclic compound containing both nitrogen and carbon atoms. This particular compound is substituted with an ethyl group at the 2-position and a methyl group at the 5-position of the benzimidazole ring. It has potential applications in pharmaceuticals, as benzimidazoles are known for their diverse biological activities and are often used as building blocks for drug development. Additionally, benzimidazole derivatives have been studied for their antimicrobial, antiviral, and anticancer properties, making this compound of interest for medicinal chemistry research.

InChI:InChI=1/C10H12N2/c1-3-10-11-8-5-4-7(2)6-9(8)12-10/h4-6H,3H2,1-2H3,(H,11,12)

Upstream product

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Relevant articles and documents

Sodium dichloroiodate promoted C-C bond cleavage: An efficient synthesis of 1,3-Benzazoles via condensation of o -amino/mercaptan/hydroxyanilines with β -diketones

An efficient aqueous sodium dichloroiodate (NaICl 2) mediated protocol is developed for the synthesis of benzofused azoles by the cyclization of 2-amino anilines/thiophenols/phenols with β-diketone compounds. The reactions gave moderate to good yield of the corresponding 2-substituted benzimidazoles/benzothiazoles/benzoxazoles under mild conditions. This tandem process involved a C-C bond cleavage and C-N bond formation. Graphical Abstract?: SYNOPSIS A facile and single protocol for the synthesis of three versatile 1,3-benzazoles viz 2-substituted 1H-benzimidazoles, benzoxazoles and benzothiazoles from readily available starting materials, 1,3-diketones and corresponding o-amino anilines/thiophenols/phenols, by aqueous sodium dichloroiodate (NaICl 2) mediated C—C bond cleavage has been developed. The reaction provides a rapid access to these 1, 3-benzazoles in good yields, thus speeding up the drug discovery process.[Figure not available: see fulltext.].

Method for preparing benzimidazole compound through supported bimetallic catalyst at room temperature

The invention belongs to the technical field of photochemistry organic synthesis, and particularly relates to a method for preparing a benzimidazole compound through a supported bimetallic catalyst at room temperature .The preparation method of the benzimidazole compound comprises the steps that o-phenylenediamine and reactant alcohol are used as initial reactants, a photocatalyst is used as a supported bimetallic nanoparticles, in an organic solvent and under the stirring condition and irradiation of ultraviolet light or visible light or sunlight, the o-phenylenediamine and the reactant alcohol are directly subjected to photocatalysis through light source irradiation to be converted into benzimidazole and a derivative thereof .According to the method, reaction conditions are mild, high-temperature reaction conditions are not needed, the reaction speed at room temperature is high, and the selectivity of the target product benzimidazole is 95% or above .

A rapid access to novel and known benzimidazole derivatives using silica chloride as a reusable catalyst

A new application of silica chloride as an easily available and reusable solid acid catalyst for the synthesis of benzimidazole and its derivatives through the condensation of o-phenylenediamines and orthoesters under thermal and solvent-free conditions is described. This novel and eco-friendly method is very cheap and has many advantages including excellent yields, short reaction time, and simple work-up procedure. Copyright