3043-79-6Relevant academic research and scientific papers
Synthesis and urease inhibitory activities of benzophenone semicarbazones/thiosemicarbazones
Arshia, Arshia,Khan, Ajmal,Khan, Khalid Mohammed,Saad, Syed Muhammad,Siddiqui, Nida Iqbal,Javaid, Sumaira,Perveen, Shahnaz,Choudhary, M. Iqbal
, p. 2666 - 2679 (2016/10/25)
Twenty-five benzophenone semicarbazones and thiosemicarbazones 3–27 were synthesized starting from benzophenones via hydrazones treated with different aryl isocyanates and isothiocyantes under reflux. All synthetic derivatives were evaluated for their urease inhibitory potential. Good to moderate inhibition trend against urease was observed with the IC50 values in the range of 8.7–119.5 μM, when compared with the standard thiourea (IC50 = 21.2 ± 1.3 μM). Compound 15 showed better inhibition than the standard having the IC50 value of 8.7 ± 0.6 μM. Compounds 3, 4, 8, 11–14, 16, and 17 with the IC50 values within the range of 26.1 to 43.6 μM, demonstrated good to moderate activities while compound 9 (IC50 = 119.5 ± 1.6 μM) displayed very weak activity. The enzyme kinetic studies on the most active compounds 15 and 17 were performed to deduce their modes of inhibition and dissociation constants Ki.
Anodic cleavage of several ketone N-phenylsemicarbazones into methyl N-phenylcarbamate and the corresponding dimethyl acetals
Nishikawa, Shinnosuke,Yamamori, Haruki,Ohashi, Kousuke,Okimoto, Mitsuhiro,Hoshi, Masayuki,Yoshida, Takashi
, p. 1766 - 1771 (2013/05/21)
Several ketone N-phenylsemicarbazones were electrooxidized in the presence of potassium iodide and a base using methanol as the solvent to give nearly commensurate amounts of methyl N-phenylcarbamate and the corresponding dimethyl acetals. Continuous evolution of gaseous nitrogen was observed from the anolyte during the electrooxidation. The reactions were carried out under very mild reaction conditions and are presumed to proceed through a four-electron oxidation process, in which the iodide ion plays an important role as an electron carrier.
