304439-23-4

Basic information

• Product Name: (3aS,6aR)-4-(5-broMopentyl)tetrahydro-1H-thieno[3,4-d]iMidazol-2(3H)-one
• Synonyms: (3aS,6aR)-4-(5-broMopentyl)tetrahydro-1H-thieno[3,4-d]iMidazol-2(3H)-one;(3aS,4S,6aR)-4-(5-Bromopentyl)tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one;(3AS,6AR)-4S-(5-BROMOPENTYL)TETRAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-2(3H)-ONE
• CAS NO: 304439-23-4
• Molecular Formula: C10H17BrN2OS
• Molecular Weight: 293.22378
• Mol File: 304439-23-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 498.3±30.0 °C(Predicted)
• Appearance: /
• Density: 1.387±0.06 g/cm3(Predicted)
• PKA: 13.90±0.40(Predicted)
• CAS DataBase Reference: (3aS,6aR)-4-(5-broMopentyl)tetrahydro-1H-thieno[3,4-d]iMidazol-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3aS,6aR)-4-(5-broMopentyl)tetrahydro-1H-thieno[3,4-d]iMidazol-2(3H)-one(304439-23-4)
• EPA Substance Registry System: (3aS,6aR)-4-(5-broMopentyl)tetrahydro-1H-thieno[3,4-d]iMidazol-2(3H)-one(304439-23-4)

Safety Data

• Hazardous Substances Data: 304439-23-4(Hazardous Substances Data)

Usage

General Description

(3aS,6aR)-4-(5-bromopentyl)tetrahydro-1H-thieno[3,4-d]imIdazol-2(3H)-one is a chemical compound with a complex molecular structure. It is classified as a thienoimidazole derivative, and it contains a bromine atom and a pentyl group. (3aS,6aR)-4-(5-broMopentyl)tetrahydro-1H-thieno[3,4-d]iMidazol-2(3H)-one may have various pharmacological properties and potential applications in medicinal chemistry, such as in the development of novel drugs for the treatment of certain diseases or conditions. Further research and evaluation of its characteristics, interactions, and effects are necessary to fully understand its potential uses and implications.

Upstream product

• 58-85-5 biotin 
• 608-16-2 biotin methyl ester 
• 53906-36-8 1H-thieno<3,4-d>imidazol-2(3H)-one, tetrahydro-4-(5-hydroxypentyl)-, <3aS-(3aα,4β,6aα)>- 
• 87573-52-2 5-[(3aS,4S,6aR)-2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl]-pentanoic acid ethyl ester 
• 69705-14-2 5-((3a5,45,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentyl 4-methylbenzenesulfonate 

Relevant articles and documents

Molecular recognition studies on naphthyridine derivatives

The association constants Kb of three hosts I-III designed to have both enhanced hydrogen bonding donor strength and conformational preorganization with biotin analogues 1-5 are reported. 1H-NMR titrations under two different concent

Triazole biotin: A tight-binding biotinidase-resistant conjugate

The natural amide bond found in all biotinylated proteins has been replaced with a triazole through CuAAC reaction of an alkynyl biotin derivative. The resultant triazole-linked adducts are shown to be highly resistant to the ubiquitous hydrolytic enzyme biotinidase and to bind avidin with dissociation constants in the low pM range. Application of this strategy to the production of a series of biotinidase-resistant biotin-Gd-DOTA contrast agents is demonstrated. The Royal Society of Chemistry 2013.

Biotin analogues with antibacterial activity are potent inhibitors of biotin protein ligase

There is a desperate need to develop new antibiotic agents to combat the rise of drug-resistant bacteria, such as clinically important Staphylococcus aureus. The essential multifunctional enzyme, biotin protein ligase (BPL), is one potential drug target f