87573-52-2

Upstream product

• 64-17-5 ethanol 
• 58-85-5 biotin 

Downstream Products

• 69705-14-2 5-((3a5,45,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentyl 4-methylbenzenesulfonate 
• 304439-23-4 (3aS,4S,6aR)-4-(5-bromo-pentyl)tetrahydrothieno[3,4-d]imidazol-2-one 

Relevant academic research and scientific papers

Directed molecular recognition: Design and synthesis of neutral receptors for biotin to bind both its functional groups

The neutral receptors 1 and 2 are designed and synthesized for the recognition of biotin, a biologically significant molecule, in chloroform to bind completely both of its functional groups simultaneously, i.e., cyclic urea and the carboxyl groups. The truncated receptor 3 binds only the cyclic urea moiety.

Biotin-tagged fluorescent sensor to visualize 'mobile' Zn2+ in cancer cells

A cancer cell-targeting fluorescent sensor has been developed to image mobile Zn2+ by introducing a biotin group. It shows a highly selective response to Zn2+in vitro, no toxicity in cellulo and images 'mobile' Zn2+ specifically in cancer cells. We believe this probe has the potential to help improve our understanding of the role of Zn2+ in the processes of cancer initiation and development.

Avidin/Biotin Bioinspired Platform for Dual in Vivo 18F-PET/NIRF Molecular Imaging

The complementary nature of positron emission tomography (PET) and near-infrared fluorescence (NIRF) imaging makes the development of innovative multimodal PET/NIRF probes a very exciting prospect. Herein, the bioinspired design of novel platform exploiting the strength and specificity of interactions between radioactive and fluorescent biotin derivatives and an avidin core is reported. The combination of an original [18F]fluoropyridinylated-biotin derivative and commercially available fluorescent biotin derivatives (Atto-425 and Atto-680) is investigated. The in vivo distribution of such a customized platform is also reported, for the first time, in healthy rodent using PET and ex vivo fluorescence imaging.

AVOIDANCE OF NON-SPECIFIC BINDING ON AN ACOUSTIC WAVE BIOSENSOR USING LINKER AND DILUENT MOLECULES FOR DEVICE SURFACE MODIFICATION

An acoustic wave biosensor comprising a surface of a mixed self-assembling monolayer for receiving a probe-biomolecule is described herein. The biosensor surface may comprise a piezoelectric quartz crystal,—for detection purposes with the electromagnetic piezoelectric acoustic sensor (EMPAS)—upon which a mixed self-assembling monolayer is formed, which includes at least one linker, such as 2,2,2-trifluoroethyl-13-trichlorosilyl-tridecanoate (TTTA); its oligoethylene glycol (OEG) analog OEGylated TTTA (OEG-TTTA); S-(2-(2-(2-(3-trichlorosilyl-propyloxy)-ethoxy)-ethoxy)-ethyl)-benzenethiosulfonate (OEG-TU BTS). Linker/diluent systems for attaching a functionalizing entity to the surface of a biosensor are described, as well as methods for preparing a biosensor surface with an oligoethylene glycol linker.

Synthesis of a biotin-derived alkyne for Pd-catalyzed coupling reactions

An efficient synthesis of a terminal alkyne derived from d-biotin was developed to provide an alternative for carboxyi-based biotinylation. This approach was illustrated by the preparation of alkyne- and alkene-linked phenylalanine derivatives using palladium-catalyzed Sonogashira and Oh methodology. (Strept)avidin binding was observed using soluble and immobilized receptors. These results demonstrate the applicability of carbon-linked biotin derivatives for use in affinity-based purification and bioanalytical applications.

Interaction of biotin with Mg-O bonds: Bifunctional binding and recognition of biotin and related ligands by the Mg(15-crown-5)2+ unit

The interaction between biotin and the macrocyclic magnesium complex Mg(15-crown-5)(Otf)2 (15-crown-5 is 1,4,7,10,13-pentaoxacyclopentadecane, Otf- is trifluoromethanesulfonate anion) in solution was studied as a model for metal-biot