304465-95-0

Upstream product

• 106-24-1 Geraniol 
• 100-39-0 benzyl bromide 
• 82188-73-6 (2S,3S)-2,3-epoxygeraniol 
• 306775-68-8 (2S,3S)-1-O-benzyl-2,3-epoxygeraniol 

Downstream Products

• 1446120-17-7 (E)-ethyl 5-((4R,5S)-5-(benzyloxymethyl)-2,2,4-trimethyl-1,3-dioxolan-4-yl)pent-2-enoate 
• 1446120-25-7 ((2R,3R)-3-(2-((4R,5S)-5-(benzyloxymethyl)-2,2,4-trimethyl-1,3-dioxolan-4-yl)ethyl)oxiran-2-yl)methanol 
• 1446120-28-0 (R)-5-((4R,5S)-5-(benzyloxymethyl)-2,2,4-trimethyl-1,3-dioxolan-4-yl)pentane-1,3-diol 
• 445493-23-2 (2S,3S,6S,7R,10R,E)-7,10-dihydroxy-2-{(S,2E,4E)-7-[(2R,3R)-3-{(2R,3S)-3-hydroxypentan-2-yl}oxiran-2-yl]-6-methylhepta-2,4-dien-2-yl}-3,7-dimethyl-12-oxooxacyclododec-4-en-6-yl acetate 
• 1446121-59-0 (R)-((1S,2S)-2-methyl-1-phenylbut-3-enyl)-3-(tert-butyldimethylsilyloxy)-5-((4R,5S)-2,2,4-trimethyl-5-vinyl-1,3-dioxolan-4-yl)pentanoate 
• 1446121-61-4 (R)-((1S,2S)-1-(4-fluorophenyl)-2-methylbut-3-enyl)-3-(tert-butyl-dimethylsilyloxy)-5-((4R,5S)-2,2,4-trimethyl-5-vinyl-1,3-dioxolan-4-yl)pentanoate 
• 1446121-63-6 (R)-((1S,2S)-2-methyl-1-p-tolylbut-3-enyl)-3-(tert-butyldimethylsilyl-oxy)-5-((4R,5S)-2,2,4-trimethyl-5-vinyl-1,3-dioxolan-4-yl)pentanoate 
• 1446121-66-9 (R)-((1S,2S)-1-(4-methoxyphenyl)-2-methylbut-3-enyl) 3-(tert-butyl dimethylsilyloxy)-5-((4R,5S)-2,2,4-trimethyl-5-vinyl-1,3-dioxolan-4-yl)pentanoate 
• 1446121-69-2 (3R,6R,7S)-((1S,2S)-2-methyl-1-phenylbut-3-enyl) 3,6,7-trihydroxy-6-methylnon-8-enoate 
• 1446121-72-7 (3R,6R,7S)-((1S,2S)-1-(4-fluorophenyl)-2-methylbut-3-enyl)-3,6,7-trihydroxy-6-methylnon-8-enoate 
• 1446121-75-0 (3R,6R,7S)-((1S,2S)-2-methyl-1-p-tolylbut-3-enyl) 3,6,7-trihydroxy-6-methylnon-8-enoate 
• 1446121-78-3 (3R,6R,7S)-((1S,2S)-1-(4-methoxyphenyl)-2-methylbut-3-enyl) 3,6,7-tri-hydroxy-6-methylnon-8-enoate 
• 1446121-81-8 (4R,7R,8S,11S,12S,E)-4,7,8-trihydroxy-7,11-dimethyl-12-phenyl-oxacyclododec-9-en-2-one 
• 1446121-84-1 (4R,7R,8S,11S,12S,E)-12-(4-fluorophenyl)-4,7,8-trihydroxy-7,11-dimethyloxacyclododec-9-en-2-one 

Relevant academic research and scientific papers

Enantioselective synthesis of pladienolide B and truncated analogues as new anticancer agents

An enantioselective synthesis of natural anticancer macrolide pladienolide B is described. The synthetic highlights include Sharpless asymmetric epoxidation, ring closing metathesis (RCM), Ireland-Claisen rearrangement, Shi epoxidation, and Pd-catalyzed S

Total synthesis of thyrsiferyl 23-acetate, a specific inhibitor of protein phosphatase 2A and an anti-leukemic inducer of apoptosis

A convergent synthetic entry to the squalenoid polyether system has been developed and applied to the biologically active marine natural products thyrsiferyl 23-acetate (1a), thyrsiferol (1b), thyrsiferyl 18-acetate (1c), and thyrsiferyl 18,23-diacetate (