304481-57-0Relevant academic research and scientific papers
Synthesis, protolytic equilibria, and antimicrobial action of nifuroxazide analogs
Gamov,Kiselev,Murekhina,Zavalishin,Aleksandriiskii,Kosterin, D.Yu.
, (2021)
The present paper reports on the synthesis of four hydrazones derived from 5-nitro-2-furfural, 5-nitro-2-thiophenal, isoniazid, 2,4- and 3,4-dihydroxy-N′-methylenebenzohydrazide. The acid-base dissociation constants of these compounds were determined in an aqueous solution. The protolytic equilibria-related ability of hydrazones to “sense” anions in dimethyl sulfoxide-containing water of different concentrations is studied using spectrophotometry, NMR spectroscopy, and quantum chemistry methods. The antimicrobial action of the hydrazones was tested and compared with that of the known drug nifuroxazide.
