30456-66-7

Basic information

• Product Name: Pyridine, 4-(2-methylphenyl)-
• CAS NO: 30456-66-7
• Molecular Formula: C12H11N
• Molecular Weight: 169.226
• Mol File: 30456-66-7.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: Pyridine, 4-(2-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 4-(2-methylphenyl)-(30456-66-7)
• EPA Substance Registry System: Pyridine, 4-(2-methylphenyl)-(30456-66-7)

Safety Data

• Hazardous Substances Data: 30456-66-7(Hazardous Substances Data)

Upstream product

• 15854-87-2 4-iodopyridine 
• 108-88-3 toluene 
• 19524-06-2 4-bromopyridine hydrochloride 
• 195062-59-0 2-methylphenylboronic acid pinacol ester 
• 7379-35-3 4-chlorpyridine hydrochloride 
• 55-22-1 pyridine-4-carboxylic acid 
• 95-46-5 2-methylphenyl bromide 
• 166401-49-6 4-(2-methylphenyl)-1,2,3,6-tetrahydropyridine 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 16419-60-6 2-Methylphenylboronic acid 
• 113964-72-0 triphenyl(pyridin-4-yl)phosphonium trifluoromethanesulfonate 
• 932-31-0 ortho-tolylmagnesium bromide 
• 110-86-1 pyridine 
• 25108-37-6 potassium pyridine-4-carboxylate 

Downstream Products

• 118931-22-9 1-methyl-4-(2-methylphenyl)pyridinium iodide 
• 5061-91-6 9H-indeno(2,1-c)pyridin-9-one 
• 133362-99-9 2-(pyridin-4-yl)benzoic acid 

Relevant articles and documents

Synthesis and metallation of 2-(pyridyl)benzoic acids and ethyl 2-(pyridyl)benzoates: A new route to azafluorenones

The ring deprotonation of 2-(2- and 4-pyridyl)benzoic acids using lithium dialkylamides in THF at rt, and the in situ cyclization afforded 4- and 2-azafluorenones, respectively. 1-Azafluorenone was obtained from ethyl 2-(3-pyridyl)benzoate using a similar protocol.

Phosphonium Salts as Pseudohalides: Regioselective Nickel-Catalyzed Cross-Coupling of Complex Pyridines and Diazines

Heterobiaryls are important pharmacophores that are challenging to prepare by traditional cross-coupling methods. An alternative approach is presented where pyridines and diazines are converted into heteroaryl phosphonium salts and coupled with aryl boronic acids. Nickel catalysts are unique for selective heteroaryl transfer, and the reaction has a broad substrate scope that includes complex pharmaceuticals. Phosphonium ions also display orthogonal reactivity in cross-couplings compared to halides, enabling chemoselective palladium- and nickel-catalyzed coupling sequences.

Palladium-catalyzed decarboxylative cross-coupling of 3-pyridyl and 4-pyridyl carboxylates with aryl bromides

Decarboxylative cross-coupling of 3-pyridyl and 4-pyridyl carboxylates with aryl bromides is reported. Using a bimetallic system of Cu2O and Pd(PPh3)4, the scope of the reaction is demonstrated by the synthesis of 27 pyridine-containing biaryls in moderate to good yields.