304665-40-5Relevant academic research and scientific papers
A versatile and regiospecific synthesis of functionalized 1,3-diarylisobenzofurans
Jacq, Jerome,Einhorn, Cathy,Einhorn, Jacques
supporting information; experimental part, p. 3757 - 3760 (2009/07/01)
(Chemical Equation Presented) A convenient, versatile, and regiospecific synthesis of functionalized 1,3-diarylisobenzofurans has been developed. It involves chemoselective addition of arylmagnesium reagents to the aldehyde function of o-aroylbenzaldehydes, themselves readily obtained by lead tetraacetate oxidation of N-aroylhydrazones of salicylaldehydes. Various functional groups, including nitro, iodo, or ester functionalities, have thus been positioned with complete regiospecificity on the 1,3-diphenylisobenzofuran backbone.
