3047-25-4

Usage

Uses

Used in Organic Synthesis:
4-(2-Chlorophenyl)but-1-ene is used as a building block in organic synthesis for the production of various compounds. Its unique structure allows for the formation of new chemical bonds and the creation of a wide range of molecules with different properties and applications.
Used in Pharmaceutical Research:
In pharmaceutical research, 4-(2-Chlorophenyl)but-1-ene is used as a starting material for the development of new drugs and pharmaceutical compounds. Its chemical properties make it a valuable component in the synthesis of potential therapeutic agents.
Used in Agrochemical Development:
4-(2-Chlorophenyl)but-1-ene may also have potential applications in the development of agrochemicals. Its chemical structure could be utilized in the creation of new pesticides, herbicides, or other agricultural chemicals to improve crop yields and protect plants from pests and diseases.
Used in Specialty Chemical Products:
Additionally, 4-(2-Chlorophenyl)but-1-ene may be used in the development of specialty chemical products, such as dyes, coatings, or adhesives. Its unique properties could contribute to the performance and functionality of these products.
It is important to handle 4-(2-Chlorophenyl)but-1-ene with caution, as it may pose risks to human health and the environment if not properly managed.

InChI:InChI=1/C10H11Cl/c1-2-3-6-9-7-4-5-8-10(9)11/h2,4-5,7-8H,1,3,6H2

Upstream product

• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 1730-25-2 allylmagnesium bromide 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 
• 106-95-6 allyl bromide 
• 1826-67-1 vinyl magnesium bromide 
• 591-87-7 Allyl acetate 
• 52372-78-8 2-chlorobenzaldehyde hydrazone 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 767-58-8 1-methylindane 
• 90875-76-6 4-(2-chlorophenyl)butan-1-ol 
• 1074764-86-5 trans-1-(but-2-en-1-yl)-2-chlorobenzene 
• 92-51-3 cyclohexylcyclohexane 
• 15499-29-3 1-butyl-2-chlorobenzene 
• 768-56-9 4-Phenylbut-1-ene 
• 104-51-8 1-butylbenzene 
• 80039-48-1 1-cyclohexyl-1,2,3,4-tetrahydro-naphthalene 
• 6992-97-8 2-(but-3-en-1-yl)aniline 
• 45892-60-2 1-(but-3-en-1-yl)-2-methylbenzene 
• 17888-40-3 1-(o-chlorophenyl)-4-(trichlorosilyl)butane 

Relevant academic research and scientific papers

Enantioselective Intermolecular C-H Amination Directed by a Chiral Cation

The enantioselective amination of C(sp3)-H bonds is a powerful synthetic transformation yet highly challenging to achieve in an intermolecular sense. We have developed a family of anionic variants of the best-in-class catalyst for Rh-catalyzed C-H amination, Rh2(esp)2, with which we have associated chiral cations derived from quaternized cinchona alkaloids. These ion-paired catalysts enable high levels of enantioselectivity to be achieved in the benzylic C-H amination of substrates bearing pendant hydroxyl groups. Additionally, the quinoline of the chiral cation appears to engage in axial ligation to the rhodium complex, providing improved yields of product versus Rh2(esp)2 and highlighting the dual role that the cation is playing. These results underline the potential of using chiral cations to control enantioselectivity in challenging transition-metal-catalyzed transformations.

Visible-Light-Induced, Base-Promoted Transition-Metal-Free Dehalogenation of Aryl Fluorides, Chlorides, Bromides, and Iodides

We report a simple and efficient visible-light-induced transition-metal-free hydrogenation of aryl halides. The combined visible light and base system is used to initiate the desired radical-mediated hydrogenation. A variety of aryl fluorides, chlorides, bromides, and iodides could be reduced to the corresponding (hetero)arenes with excellent yields under mild conditions. Various functional groups and other heterocyclic compounds are tolerated.

Bench-Stable Nickel Precatalysts with Heck-type Activation

Herein, we report the synthesis and characterization of a new class of air- and moisture-stable phosphine-containing nickel(II) precatalysts, which activate through a Heck-type mechanism. The activities of the precatalysts are demonstrated with a carbonyl

Umpolung of Carbonyl Groups as Alkyl Organometallic Reagent Surrogates for Palladium-Catalyzed Allylic Alkylation

Palladium-catalyzed allylic alkylation of nonstabilized carbon nucleophiles is difficult and remains a major challenge. Reported here is a highly chemo- and regioselective direct palladium-catalyzed C-allylation of hydrazones, generated from carbonyls, as a source of umpolung unstabilized alkyl carbanions and surrogates of alkyl organometallic reagents. Contrary to classical allylation techniques, this umpolung reaction utilizes hydrazones prepared not only from aryl aldehydes but also from alkyl aldehydes and ketones as renewable feedstocks. This strategy complements the palladium-catalyzed coupling of unstabilized nucleophiles with allylic electrophiles by providing an efficient and selective catalytic alternative to the traditional use of highly reactive alkyl organometallic reagents.

Asymmetric dihydroxylation of aryl allyl ethers

Asymmetric dihydroxylation of substituted aryl allyl ethers is described. Para-substituents are shown to favor high enantioselectivity (89-95%ee), while ortho-groups have a deleterious effect (28-63%ee). Four medicinal agents were prepared: guaifenesin (expectorant), mephenesin (muscle relaxant), chlorphenesin (antifungal) and propanolol (β-blocker).