304859-87-8

Upstream product

• 77-78-1 dimethyl sulfate 
• 304859-86-7 (1'S)-2-bromo-3,4-dihydroxy-5-(1',2',2'-trimethylcyclopentyl)benzaldehyde 
• 223751-48-2 (1'S)-1-bromo-2,3-dimethoxy-6-methyl-4-(1',2',2'-trimethylcyclopentyl)benzene 
• 185967-11-7 (1'S)-3,4-dihydroxy-5-(1,2,2-trimethylcyclopentyl)benzaldehyde 
• 328533-38-6 (1'S)-2-Bromo-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)phenyl-1-methanol 

Downstream Products

• 304859-79-8 (1''S,1'''S)-[2'-methoxy-5'-methyl-3'-(1''',2''',2'''-trimethylcyclopentyl)-phenyl] 2-bromo-3,4-dimethoxy-5-(1'',2'',2''-trimethylcyclopentyl)benzoate 
• 223751-40-4 (1'S)-2-bromo-3,4-dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzoic acid 
• 222022-91-5 (1'S)-3,4-Dimethoxy-5-(1',2',2'-trimethylcyclopentyl)benzaldehyde 

Relevant academic research and scientific papers

From dynamic to non-dynamic kinetic resolution of lactone-bridged biaryls: Synthesis of mastigophorene B

The atroposelective ring cleavage of configurationally unstable biaryl lactones, by dynamic kinetic resolution, is an efficient tool for the stereoselective synthesis of axially chiral biaryl target molecules. The recent extension of this methodology to the kinetic resolution of configurationally stable biaryl lactones and its application to natural product synthesis is described herein, exemplarily for the preparation of the nerve-growth stimulating dimeric sesquiterpene mastigophorene B.

Nondynamic and dynamic kinetic resolution of lactones with stereogenic centers and axes: Stereoselective total synthesis of herbertenediol and mastigophorenes A and B

The stereoselective total synthesis of the sesquiterpene herbertenediol (3) and of its naturally occurring dimers, mastigophorenes A [(P)-1] and B [(M)-1], is described. Following the 'lactone concept', the configuration at the biaryl axis was atropo-dive