304884-77-3Relevant academic research and scientific papers
Structure-Based Design of Novel Biphenyl Amide Antagonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 8 Channels with Potential Implications in the Treatment of Sensory Neuropathies
Journigan, V. Blair,Feng, Zhiwei,Rahman, Saifur,Wang, Yuanqiang,Amin, A. R. M. Ruhul,Heffner, Colleen E.,Bachtel, Nicholas,Wang, Siyi,Gonzalez-Rodriguez, Sara,Fernández-Carvajal, Asia,Fernández-Ballester, Gregorio,Hilton, Jacob K.,Van Horn, Wade D.,Ferrer-Montiel, Antonio,Xie, Xiang-Qun,Rahman, Taufiq
, p. 268 - 290 (2020)
Structure-activity relationship studies of a reported menthol-based transient receptor potential cation channel subfamily M member 8 channel (TRPM8) antagonist, guided by computational simulations and structure-based design, uncovers a novel series of TRP
TRANSIENT RECEPTOR POTENTIAL MELASTATIN 8 (TRPM8) ANTAGONISTS AND RELATED METHODS
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Paragraph 00117-00118; 00123, (2020/08/22)
A TRPM8 antagonist is provided that comprises the following the formula (I) described herein. In the formula (I), R1 is selected from a cycloalkyl, a bicycloalkyl, or a tricycloalkyl group. Each R1 group has 5 to 12 carbon atoms. Fur
Oxidative Amidation of Amines in Tandem with Transamidation: A Route to Amides Using Visible-Light Energy
Nandi, Jyoti,Vaughan, Matthew Z.,Sandoval, Arturo León,Paolillo, Joshua M.,Leadbeater, Nicholas E.
, p. 9219 - 9229 (2020/08/14)
A methodology is reported for preparing amides using amines as an acyl source. The protocol involves the visible-light-promoted oxidative amidation of amines with pyrazole to synthesize N-acyl pyrazoles followed by transamidation. By combining photoredox catalysis with oxoammonium cations in the presence of sodium persulfate as a terminal oxidant, the N-acyl pyrazoles could be prepared efficiently and effectively using blue LEDs. The transamidation step was performed without the need to purify the N-acyl pyrazole intermediate, and a range of amides were generated in good to excellent yields.
Trimethylaluminium-facilitated direct amidation of carboxylic acids
Chung, Seungwon,Uccello, Daniel P.,Choi, Huiwon,Montgomery, Justin I.,Chen, Jinshan
scheme or table, p. 2072 - 2074 (2011/10/08)
Free carboxylic acids are converted into amides in moderate to high yields in the presence of a stoichiometric amount of trimethylaluminium and amines at 90°C after 1 hour. Georg Thieme Verlag Stuttgart - New York.
