3049-19-2Relevant academic research and scientific papers
DBU-promoted alkylation of alkyl phosphinates and H-phosphonates
Gavara, Laurent,Petit, Christelle,Montchamp, Jean-Luc
supporting information, p. 5000 - 5003 (2012/11/07)
The alkylation of alkyl phosphinates and some H-phosphonate diesters is promoted by the base DBU. Only more reactive alkyl halides react in preparatively useful yields. However, the method provides easy access to important H-phosphinate building blocks, without the need for a protecting group strategy or metal catalysts. The reaction is conveniently conducted at, or below, room temperature. The preparation of methyl-H-phosphinate esters is particularly interesting as it avoids the heretofore more common use of methyldichlorophosphine MePCl2.
Mild and efficient Cs2CO3-promoted synthesis of phosphonates
Cohen, Richard J.,Fox, Daniel L.,Eubank, Jarrod F.,Salvatore, Ralph Nicholas
, p. 8617 - 8621 (2007/10/03)
A mild and convenient synthesis for phosphonates using cesium carbonate (Cs2CO3), tetrabutylammonium iodide (TBAI) and DMF was developed at room temperature. Numerous dialkyl phosphites were screened using a diverse array of alkyl halides and these reaction conditions were found to be highly efficient producing various phosphonates exclusively in moderate to high yields.
