30512-65-3

Basic information

• Product Name: Propanoic acid, 3-[(4-hydroxyphenyl)thio]-
• CAS NO: 30512-65-3
• Molecular Formula: C9H10O3S
• Molecular Weight: 198.243
• Mol File: 30512-65-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 3-[(4-hydroxyphenyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 3-[(4-hydroxyphenyl)thio]-(30512-65-3)
• EPA Substance Registry System: Propanoic acid, 3-[(4-hydroxyphenyl)thio]-(30512-65-3)

Safety Data

• Hazardous Substances Data: 30512-65-3(Hazardous Substances Data)

Upstream product

• 107-94-8 chloropropionic acid 
• 637-89-8 4-sulfanylphenol 
• 590-92-1 3-Bromopropionic acid 

Relevant articles and documents

Design, synthesis, antifungal activity and molecular docking of thiochroman-4-one derivatives

N-Myristoyltransferase (NMT) has been validated pre-clinically as a target for treatment of fungal infections. Various substituted thiochroman-4-one derivatives have been synthesized by an efficient method. The synthesized compounds 7a–y and 8a–t were evaluated for their in vitro antifungal activity against the Canidia albicans, Cryptococcus neoformans, Epidermophyton floccosum, Mucor racemosus, Microsporum gypseum and Aspergillus nigerstrain. A series of compounds exhibited significant activity (minimal inhibitory concentrotion (MIC)=0.5–16μg/mL) against Canidia albicans and Cryptococcus neoformans. The antifungal activity of compound 7b was reached to that of fluconazole, which can serve as a good starting point for further studies of structural diversity of the NMT inhibitors. The molecular docking studies revealed an interesting binding profile with very high receptor affinity for NMT of Canidia albicans.

TRICYCLIC PYRAZOL AMINE DERIVATIVES

This invention relates to compounds of Formula (I*) as Pi3k inhibitors for treating autoimmune diseases, inflammatory disorders, multiple sclerosis and other diseases like cancers.