305352-01-6Relevant academic research and scientific papers
Preparation of the Serotonin Transporter PET Radiotracer 2-({2-[(Dimethylamino)methyl]phenyl}thio)-5-[18 F]fluoroaniline (4-[18 F]ADAM): Probing Synthetic and Radiosynthetic Methods
Aigbirhio, Franklin I.,Milicevic Sephton, Selena,Thompson, Stephen,Zhou, Xiaoyun
, p. 4374 - 4384 (2019/11/21)
Serotonin transporters (SERTs) are involved in regulating the concentration of synaptic serotonin and present a good target for many neurologic and psychiatric disorder drugs. Positron-emission tomography (PET) is a valuable tool in both diagnosis and mon
Fluorinated phenyl thiophenyl derivatives and their use for imaging serotonin transporters
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Page 3; 4; 11, (2008/06/13)
This invention relates to novel fluorinated phenyl thiphenyl (also named diarylsulfide) derivatives and their use in Positron Emission Tomagraphy (PET) imaging of Serotonin Transporters (SERTS). The present invention also provides diagnostic compositions comprising the novel compounds of the present invention, and a pharmaceutically acceptable carrier or diluent. The invention further provides a method of imaging SERTS, comprising introducing into a patient a detectable quantity of a labeled compound of the present invetion, or a pharmaceutically acceptable salt, ester, amide or prodrug thereof.
Substituted diphenyl sulfides as selective serotonin transporter ligands: Synthesis and in vitro evaluation
Emond, Patrick,Vercouillie, Johnny,Innis, Robert,Chalon, Sylvie,Mavel, Sylvie,Frangin, Yves,Halldin, Christer,Besnard, Jean-Claude,Guilloteau, Denis
, p. 1253 - 1258 (2007/10/03)
A series of diphenyl sulfide derivatives substituted at the 1-, 2′-, and 4′-positions has been synthesized and evaluated for their in vitro affinities at the dopamine, serotonin (SERT), and norepinephrine transporters. The examination of Ki val
