305352-04-9Relevant academic research and scientific papers
Preparation of the Serotonin Transporter PET Radiotracer 2-({2-[(Dimethylamino)methyl]phenyl}thio)-5-[18 F]fluoroaniline (4-[18 F]ADAM): Probing Synthetic and Radiosynthetic Methods
Aigbirhio, Franklin I.,Milicevic Sephton, Selena,Thompson, Stephen,Zhou, Xiaoyun
, p. 4374 - 4384 (2019/11/21)
Serotonin transporters (SERTs) are involved in regulating the concentration of synaptic serotonin and present a good target for many neurologic and psychiatric disorder drugs. Positron-emission tomography (PET) is a valuable tool in both diagnosis and mon
Method for preparing radiotracer precursor SnADAM
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, (2015/09/22)
A method for preparing a radiotracer precursor SnADAM is revealed. The method overcomes shortcomings of conventional synthesis methods including lower yield rate and time-consuming. Moreover, Pd/C catalyst and hydrogen gas are used to catalyze reduction reaction for avoiding the generation of a large amount of intermediate products with similar structures. Thus there is no need to perform isolation and purification processes. The yield rate of the intermediate products is also increased so that its impact on the low yield rate of the final product SnADAM is minimized. A part of the reaction is significantly accelerated by using tris(dibenzylideneacetone)-dipalladium(0) (Pd2(dba)3) as a catalyst. Thus the production time of SnADAM is shortened.
Substituted diphenyl sulfides as selective serotonin transporter ligands: Synthesis and in vitro evaluation
Emond, Patrick,Vercouillie, Johnny,Innis, Robert,Chalon, Sylvie,Mavel, Sylvie,Frangin, Yves,Halldin, Christer,Besnard, Jean-Claude,Guilloteau, Denis
, p. 1253 - 1258 (2007/10/03)
A series of diphenyl sulfide derivatives substituted at the 1-, 2′-, and 4′-positions has been synthesized and evaluated for their in vitro affinities at the dopamine, serotonin (SERT), and norepinephrine transporters. The examination of Ki val
