305351-97-7

Upstream product

• 3460-18-2 1,4-dibromo-2-nitrobenzene 
• 20877-02-5 2-thio-N,N-dimethylbenzamide 
• 506-59-2 N,N-dimethylammonium chloride 
• 147-93-3 Thiosalicylic acid 
• 124-40-3 dimethyl amine 
• 865168-52-1 2-(4-bromo-2-nitro-phenylsulfanyl)-benzoyl chloride 
• 544710-44-3 2-[(4-bromo-2-nitrophenyl)thio]benzoic acid 

Downstream Products

• 606937-82-0 N,N-dimethyl-2-(2-nitro-4-bromophenylthio)benzylamine.BH₃ 
• 305352-01-6 1-(2-((4-bromo-2-nitrophenyl)thio)phenyl)-N,N-dimethylmethanamine 
• 305352-04-9 5-bromo-2-((2-((dimethylamino)methyl)phenyl)thio)aniline 

Relevant academic research and scientific papers

Preparation of the Serotonin Transporter PET Radiotracer 2-({2-[(Dimethylamino)methyl]phenyl}thio)-5-[18 F]fluoroaniline (4-[18 F]ADAM): Probing Synthetic and Radiosynthetic Methods

Serotonin transporters (SERTs) are involved in regulating the concentration of synaptic serotonin and present a good target for many neurologic and psychiatric disorder drugs. Positron-emission tomography (PET) is a valuable tool in both diagnosis and mon

Method for preparing radiotracer precursor SnADAM

A method for preparing a radiotracer precursor SnADAM is revealed. The method overcomes shortcomings of conventional synthesis methods including lower yield rate and time-consuming. Moreover, Pd/C catalyst and hydrogen gas are used to catalyze reduction reaction for avoiding the generation of a large amount of intermediate products with similar structures. Thus there is no need to perform isolation and purification processes. The yield rate of the intermediate products is also increased so that its impact on the low yield rate of the final product SnADAM is minimized. A part of the reaction is significantly accelerated by using tris(dibenzylideneacetone)-dipalladium(0) (Pd2(dba)3) as a catalyst. Thus the production time of SnADAM is shortened.

Fluorinated phenyl thiophenyl derivatives and their use for imaging serotonin transporters

This invention relates to novel fluorinated phenyl thiphenyl (also named diarylsulfide) derivatives and their use in Positron Emission Tomagraphy (PET) imaging of Serotonin Transporters (SERTS). The present invention also provides diagnostic compositions comprising the novel compounds of the present invention, and a pharmaceutically acceptable carrier or diluent. The invention further provides a method of imaging SERTS, comprising introducing into a patient a detectable quantity of a labeled compound of the present invetion, or a pharmaceutically acceptable salt, ester, amide or prodrug thereof.