305381-67-3

Basic information

• Product Name: 1-METHYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID
• Synonyms: 1-METHYL-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID;1-METHYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID;1-methyl-1H-benzo[d][1,2,3]triazole-5-carboxylic acid;1H-Benzotriazole-5-carboxylicacid, 1-Methyl-;1-methylbenzotriazole-5-carboxylic acid
• CAS NO: 305381-67-3
• Molecular Formula: C₈H₇N₃O₂
• Molecular Weight: 177.16
• Mol File: 305381-67-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 250 °C
• Boiling Point: 432.4°Cat760mmHg
• Flash Point: 215.3°C
• Appearance: /
• Density: 1.49g/cm³
• Vapor Pressure: 3.03E-08mmHg at 25°C
• Refractive Index: 1.704
• Storage Temp.: 2-8°C
• PKA: 3.51±0.30(Predicted)
• CAS DataBase Reference: 1-METHYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID(305381-67-3)
• EPA Substance Registry System: 1-METHYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID(305381-67-3)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• Hazardous Substances Data: 305381-67-3(Hazardous Substances Data)

Usage

General Description

1-Methyl-1H-1,2,3-benzotriazole-5-carboxylic acid is a chemical compound with potential applications in various industries, including the pharmaceutical, agricultural, and chemical sectors. It is a derivative of 1,2,3-benzotriazole, containing a carboxylic acid group and a methyl group attached to the benzotriazole ring. 1-METHYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID is known for its corrosion inhibition properties and is often used as a corrosion inhibitor in metalworking fluids, cooling water systems, and oil and gas production. Additionally, it has been studied for its potential antifungal and antimicrobial activities, making it of interest for the development of new pharmaceuticals and agrochemicals. Overall, 1-methyl-1H-1,2,3-benzotriazole-5-carboxylic acid has a wide range of industrial applications and potential biological activities, making it an important chemical compound in various fields.

InChI:InChI=1/C8H7N3O2/c1-11-7-3-2-5(8(12)13)4-6(7)9-10-11/h2-4H,1H3,(H,12,13)

Upstream product

• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 41263-74-5 4-(methylamino)-3-nitrobenzoic acid 
• 66315-16-0 methyl 3-amino-4-(methylamino)benzoate 
• 36242-50-9 4-methylamino-3-nitro-benzoic acid methyl ester 
• 66315-15-9 3-amino-4-(methylamino)benzoic acid 

Downstream Products

• 499785-52-3 ethyl 1-methyl-1H-benzo[d][1,2,3]triazole-5-carboxylate 
• 423768-38-1 1-methyl-1H-1,2,3-benzotriazole-5-carbonyl chloride 
• 305381-87-7 cyclohexen-3-on-1-yl 1-methylbenzotriazole-5-carboxylate 

Relevant articles and documents

The discovery of new scaffold of plant activators: From salicylic acid to benzotriazole

Started from salicylic acid (SA) and related commercialized plant activators, based on molecular three-dimensional shape and pharmacophore similarity comparison (SHAFTS), a new lead compound benzotriazole was predicted and a series of benzotriazole derivatives were designed and synthesized. The bioassay showed that benzotriazole had high activity against a broad spectrum of diseases including fungi and oomycetes in vivo, but no activity in vitro. And the introduction of proper groups at the 1’-position and 5’-position was beneficial to the activity. So, they had the potential to be exploited as novel plant activators.

INHIBITORS OF HISTONE DEACETYLASE

The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.