30563-27-0

Usage

Uses

Used in Fragrance and Perfume Industry:
Benzyl nitroacetate is utilized as a key ingredient in the creation of various fragrances and perfumes, capitalizing on its appealing fruity scent to enhance the olfactory experience of consumers. Its unique aroma profile contributes to the complexity and richness of scent compositions in this industry.
Used in Chemical Research and Development:
Due to its chemical properties, benzyl nitroacetate serves as a valuable compound in research and development within the chemical industry. It can be used in the synthesis of other organic compounds and as a model for studying the behavior of nitro compounds in various chemical reactions.
Used in Hazardous Material Education and Training:
Given its classification as a hazardous chemical, benzyl nitroacetate is also employed in educational and training programs to teach proper handling, storage, and safety measures. This helps to ensure that individuals who work with such chemicals are well-prepared to manage risks and prevent accidents in professional settings.

Upstream product

• 2483-57-0 methyl 2-nitroacetate 
• 100-51-6 benzyl alcohol 
• 625-75-2 nitroacetic acid 

Downstream Products

• 31283-09-7 4-indol-3-yl-2-oxy-4,5-dihydro-isoxazole-3,5-dicarboxylic acid dibenzyl ester 
• 31283-08-6 4-(1-acetyl-indol-3-yl)-2-oxy-4,5-dihydro-isoxazole-3,5-dicarboxylic acid dibenzyl ester 
• 15151-92-5 2-Nitro-2-benzyloxycarbonyl-cyclohexandiol-1,3 
• 15151-93-6 1,3-Dihydroxy-2-nitro-2-aethoxycarbonyl-indan 
• 103218-02-6 benzyl fluoronitroacetate 
• 58581-52-5 1-(Benzyloxycarbonyl)-methylhydroxylamine 
• 31140-45-1 (+/-)-2-Nitro-3-<2,4,5-tribenzyloxy-phenyl>-propionsaeure-benzylester 
• 534569-86-3 benzyl 2-diazo-2-nitroacetate 
• 64995-22-8 3,3-Diethoxy-2-nitro-propionic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis of Psychrophilin e

The first total synthesis of psychrophilin E, a potent antiproliferative cyclic tripeptide isolated from Aspergillus versicolor ZLN-60, is reported herein. Key features of the synthesis include the installation of an amide bond between the indole-nitrogen of tryptophan and an anthranilic acid residue, and a high yielding macrolactamization of the linear tripeptide to the desired macrocycle.

An efficient procedure for the esterification of nitroacetic acid :Application to the preparation of Merrifield resin-bound nitroacetate

Nitroacetic esters are prepared in good yield by reaction, at 0 °C, of nitroacetic acid with various alcohols in the presence of DCC. These reaction conditions were applied to the preparation of Merrifield resin-bound nitroacetate.

Transesterification of Methyl 2-Nitroacetate to Superior Esters

Methyl 2-nitroacetate and methyl acetoacetate have in common the presence of an electron-withdrawing substituent geminal to the methyl ester function but the well-known ease of thermal transesterification of methyl acetoacetate has not been found in methyl 2-nitroacetate. The latter gives uncatalysed thermal transesterification only in low yield and at a temperature higher than that of methyl acetoacetate. Comparative experiments provided further insight into the reactions; protic and Lewis acid catalysts promoted the smooth exchange of the alkanoyl groups, observing first the transesterification of methyl 2-nitroacetate with ethanol, already proved difficult to proceed. Dibutyltin(IV)oxide (DBTO) catalyst offered the spur to set up a convenient synthetic methodology from methyl 2-nitroacetate, encompassing higher molecular weight and functionalised alcohols: aliphatic, unsaturated and oxidation sensitive species were suited to react, delivering the corresponding 2-nitroacetate esters in good yields in most cases.