5006-79-1

Usage

General Description

1H-Imidazole, 1-ethenyl-2-methyl-5-nitro- is a chemical compound with the molecular formula C7H7N3O2. It is a nitroimidazole derivative that has been studied for its potential use as an antimicrobial and antiparasitic agent. The presence of a nitro group in the molecule gives it the ability to act as a DNA modifying agent, making it effective against certain protozoa and anaerobic bacteria. This chemical also has potential as an anti-cancer agent due to its ability to induce apoptosis in cancer cells. Additionally, it has shown promise as a radiosensitizer in cancer therapy, enhancing the effectiveness of radiation treatment on tumors. However, more research is needed to fully understand the pharmacological properties and potential applications of 1H-Imidazole, 1-ethenyl-2-methyl-5-nitro-.

Upstream product

• 30575-42-9 toluene-4-sulfonic acid 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester 
• 696-23-1 2-methyl-5-nitro-1H-imidazole 
• 106-93-4 ethylene dibromide 
• 443-48-1 metronidazole 

Relevant academic research and scientific papers

Alkylated/aminated nitroimidazoles and nitroimidazole-7-chloroquinoline conjugates: Synthesis and anti-mycobacterial evaluation

The success in exploring anti-tubercular potency of nitroimidazole and quinoline, the core moieties of recently approved anti-tubercular drugs instigated us to synthesize a series of alkylated/aminated 2-methyl-5-nitroimidazoles and nitroimidazole-7-chloroquinoline conjugates and to evaluate them for their activities against Mycobacterium tuberculosis as well as for their cytotoxicity towards the J774 murine macrophage cell line. Although the synthesized compounds did not surpass the activity of the standard drug Isoniazid, they have appreciable activities with minimal cytotoxicity. The synthesized nitroimidazole-7-chloroquinoline conjugate, 11c, having butyl chain as linker, proved to be the most potent among the series with an MIC50 value of 2.2 μg/mL.

N-vinyl-nitroimidazole cycloadditions: Potential routes to nucleoside analogues

Cycloaddition reactions of 4-nitro- and 5-nitro-1-vinylimidazoles have been investigated. The cycloadducts obtained are potential intermediates for synthesis of purine nucleoside analogues via reduction to the corresponding aminoimidazoles. A byproduct obtained using benzonitrile oxide as 1,3-dipolarophile has been identified as a novel tricyclic isomer 12 of the cycloadduct 11. Georg Thieme Verlag Stuttgart.