305798-03-2

Basic information

• Product Name: 2-Naphthaleneacetonitrile, 6-bromo-
• Synonyms: 6-Bromo-2-naphthaleneacetonitrile;2-Naphthaleneacetonitrile, 6-bromo-;2-(6-BroMonaphthalen-2-yl)acetonitrile
• CAS NO: 305798-03-2
• Molecular Formula: C₁₂H₈BrN
• Molecular Weight: 246.1
• Mol File: 305798-03-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 118-119 °C
• Boiling Point: 389.4±17.0 °C(Predicted)
• Appearance: /
• Density: 1.483±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-Naphthaleneacetonitrile, 6-bromo-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Naphthaleneacetonitrile, 6-bromo-(305798-03-2)
• EPA Substance Registry System: 2-Naphthaleneacetonitrile, 6-bromo-(305798-03-2)

Safety Data

• Hazardous Substances Data: 305798-03-2(Hazardous Substances Data)

Usage

General Description

6-bromo-2-naphthaleneacetonitrile is a chemical compound with the molecular formula C12H8BrN. It is a nitrile compound with a bromine atom attached to the 6th position on the naphthalene ring. 2-Naphthaleneacetonitrile, 6-bromo- is often used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is known for its wide range of applications in the field of organic chemistry, including as a building block in the production of complex organic molecules. Additionally, it has been studied for its potential biological activities, making it an important target for further research in the development of new drugs and chemical compounds.

Upstream product

• 33626-98-1 methyl 6-bromo-2-naphthoate 
• 773837-37-9 sodium cyanide 
• 689290-84-4 2-bromo-6-(chloromethyl)naphthalene 
• 5773-80-8 6-bromo-2-naphthoic acid 
• 100751-63-1 (6-bromo-2-naphthy)methanol 
• 143-33-9 sodium cyanide 

Downstream Products

• 689290-86-6 4-[6-(2-hydroxyethyl)-2-naphthyl]benzonitrile 
• 693773-64-7 methanesulfonic acid 2-[6-(4-cyano-phenyl)-naphthalen-2-yl]-ethyl ester 
• 689290-83-3 4-(6-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-2-naphthyl)benzonitrile 
• 1423691-32-0 C₂₈H₂₄N₂O₄S 
• 1423685-07-7 C₂₇H₂₂N₂O₄S 

Relevant articles and documents

Three-component asymmetric catalytic ugi reaction - Concinnity from diversity by substrate-mediated catalyst assembly

The first chiral catalyst for the three-component Ugi reaction was identified as a result of a screen of a large set of different BOROX catalysts. The BOROX catalysts were assembled in situ from a chiral biaryl ligand, an amine, water, BH3×SMe2, and an alcohol or phenol. The catalyst screen included 13 different ligands, 12 amines, and 47 alcohols or phenols. The optimal catalyst system (LAP 8-5-47) provided α-amino amides from an aldehyde, a secondary amine, and an isonitrile with excellent asymmetric induction. The catalytically active species is proposed to be an ion pair that consists of the chiral boroxinate anion and an iminium cation. Harmonious arrangement of parts: A screen of BOROX catalysts that were generated in situ from 13 different ligands and 47 alcohols led to the identification of an effective combination for the catalytic asymmetric three-component Ugi reaction. Experimental results suggest that the catalyst is a chiral polyborate anion, which then forms an ion pair with the iminium cation that is generated from aldehyde and secondary amine.

4-[6-(2-Aminoethyl)naphthalen-2-yl]benzonitriles are potent histamine H3 receptor antagonists with high CNS penetration

4-[6-(2-Tertiaryaminoethyl)naphthalen-2-yl]benzonitriles are conformationally constrained histamine H3 receptor antagonists with high potency and selectivity. The analogs were designed around a naphthalene core, with the goal of enhancing lipop

Bicyclic-substituted amines as histamine-3 receptor ligands

Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands and methods for using such comp