305816-04-0Relevant articles and documents
Solution-phase preparation of a 560-compound library of individual pure mappicine analogues by fluorous mixture synthesis
Zhang, Wei,Luo, Zhiyong,Chen, Christine Hiu-Tung,Curran, Dennis P.
, p. 10443 - 10450 (2002)
Solution-phase mixture synthesis has efficiency advantages and favorable reaction kinetics. Applications of this technique, however, have been discouraged by the difficulty in obtaining individual, pure final products by using conventional separation and
Reaction and separation methods
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, (2008/06/13)
A method of separating compounds that includes the steps of: tagging at least a first organic compound with a first tagging moiety to result in a first tagged compound; tagging at least a second organic compound with a second tagging moiety different from
MAPPICINE ANALOGS, INTERMEDIATES IN THE SYNTHESIS OF MAPPICINE ANALOGS AND METHODS OF SYNTHESIS OF MAPPICINE ANALOGS
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Page/Page column 55, (2010/02/07)
A compound having the following structure: (I) wherein Z is -CHOR1R2 or -C(O)R2; R1 is H, an alkyl group, an aryl group, -OC(O)ORa, wherein Ra is an alkyl group, -C(O)Rb wherein Rb is an alkyl group, an aryl group, an alkoxy group, an amino group, an alkylamino group, a dialkylamino group, an aryl amino group, a diarylamino group, an arylalkyl amino group, a protecting group or a fluorous tag; R2 is an alkyl group, an aryl group or an arylalkyl group; R3 is H, an alkyl group, hydroxyalkyl group or an aryl group; R4-R8 are independently the same or different and are hydrogen, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, an alkoxy group, an aryloxy group, an acyloxy group, a haloalkyl group, a perfluoroalkyl group, fluorine, chlorine, bromine, a haloalkyloxy group, a carbamoyloxy group, a hydroxy group, a nitro group, a cyano group, a cyanoalkyl group, an azido group, an azidoalkyl group, a formyl group, a hydrazino group, a hydrazinoalkyl group, a hydroxyalkyl group, an alkoxyalkyl group, -NR1Rm, wherein R1 and Rm are independently hydrogen, an alkyl group, an aryl group, an arylalkyl group, or -C(O)Rb, an aminoalkyl group, an alkylaminoalkyl group, a dialkylaminoalkyl group, an aryl aminoalkyl group, a diarylaminoalkyl group, an arylalkyl aminoalkyl group, -OC(O)ORa, wherein Ra is an alkyl group, -C(O)Rb, -SRC, S(O)Rc or S(O2)Rc wherein Rc is hydrogen, -C(O)Rb, an alkyl group, or an aryl group, (CH2)nSiRdReRf wherein n is an integer within the range of 0 through 10 and Rd, Re and Rf are independently a C1-10 alkyl group, a C2-10 alkenyl group, a C2-10 alkynyl group, an aryl group, a haloalkyl group, a cyanoalkyl group, an azidoalkyl group, a hydrazinoalkyl group, a hydroxyalkyl group, an alkoxyalkyl group, an aminoalkyl group, an alkylaminoalkyl group, a dialkylaminoalkyl group, an aryl aminoalkyl group, a diarylaminoalkyl group, an arylalkyl aminoalkyl group. Alternatively R4 and R5, R6 and R6; R6 and R7; or R7 and R8 can form together a chain of 3 or four groups selected from CH, CH2, O, S, N, NH, N-alkyl or N-aryl. Provided that, at least one of R5-R7 is not H, a lower alkyl group, fluorine, a cyano group, a hydroxyl group, hydroxyalkyl group, an alkoxy group, an aminoalkyl group, an alkylaminoalkyl group, a dialkylaminoalkyl group, an amino group, an alkylamino group, a dialkylamino group, a carbamoyloxy group, a formyl group or -C(O)Rx wherein Rx is an alkyl group.