170453-55-1

Basic information

• Product Name: Pyridine, 2-methoxy-6-(trimethylsilyl)- (9CI)
• Synonyms: Pyridine, 2-methoxy-6-(trimethylsilyl)- (9CI)
• CAS NO: 170453-55-1
• Molecular Formula: C₉H₁₅NOSi
• Molecular Weight: 181.307
• Product Categories: SILYL
• Mol File: 170453-55-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyridine, 2-methoxy-6-(trimethylsilyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-methoxy-6-(trimethylsilyl)- (9CI)(170453-55-1)
• EPA Substance Registry System: Pyridine, 2-methoxy-6-(trimethylsilyl)- (9CI)(170453-55-1)

Safety Data

• Hazardous Substances Data: 170453-55-1(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 40473-07-2 6-bromo-2-methoxypyridine 

Downstream Products

• 174092-79-6 (S)-4-ethyl-4-hydroxy-6-iodo-8-methoxy-1,4-dihydro-pyrano[3,4-c]pyridin-3-one 
• 149882-10-0 lurtotecan 
• 7689-03-4 camptothecin 
• 86639-52-3 7-ethyl-10-hydroxycamptothecin 
• 19685-10-0 10-methoxycamptothecin 
• 19685-09-7 (S)-10-hydroxycamptothecin 
• 110351-92-3 (R)-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H)-dione 
• 174092-76-3 3-(2-butenyloxymethyl)-4-iodo-2-methoxy-6-trimethylsilylpyridine 
• 174092-78-5 (S)-(+)-4-ethyl-4-hydroxy-8-methoxy-6-(trimethylsilyl)-1,4-dihydro-3H-pyrano[3,4-c]pyridin-3-one 
• 174092-77-4 4-Ethyl-8-methoxy-6-trimethylsilanyl-1H-pyrano[3,4-c]pyridine 
• 305816-16-4 3-cyclohexyl-1-(2-methoxy-3-methyl-6-trimethylsilanyl-pyridin-4-yl)-propan-1-ol 
• 463946-46-5 cyclohexyl-(2-methoxy-3-methyl-6-trimethylsilanyl-pyridin-4-yl)-methanol 
• 375346-05-7 [4-iodo-2-methoxy-6-(trimethylsilanyl)pyridin-3-yl]methanol 
• 305816-04-0 4-Iodo-2-methoxy-3-methyl-6-trimethylsilylpyridine 

Relevant articles and documents

Lithiation of 2-chloro- and 2-methoxypyridine with lithium dialkylamides: Initial ortho-direction or subsequent lithium ortho-stabilization?

The lithiation pathway of 2-chloro and 2-methoxypyridine with LDA and LTMP has been investigated using deuterated probes. The availability of both H-6 and H-3 protons on the pyridine nucleus was found to be critical to ensure complete C-3 lithiation. We thus concluded that the C-3 lithiation was not a straightforward process. A mechanism involving precomplexation of lithium dialkylamides near the H-6 proton and formation of a 3,6-dilithio pyridine intermediate is proposed.