305837-97-2

Upstream product

• 100-42-5 styrene 
• 124070-40-2 4-methyl-N-(4-methylpent-1-en-3-yl)benzenesulfonamide 
• 353264-99-0 N-isobutylidene-4-methylbenzenesulfonamide 
• 70-55-3 toluene-4-sulfonamide 
• 100-52-7 benzaldehyde 
• 98-59-9 p-toluenesulfonyl chloride 
• 305837-96-1 (E)-4-methyl-1-phenylpent-1-en-3-amine 

Relevant academic research and scientific papers

Alkenyl Exchange of Allylamines via Nickel(0)-Catalyzed C-C Bond Cleavage

A functional group exchange reaction between allylamines and alkenes via nickel-catalyzed C - C bond cleavage and formation was developed. This reaction provides a novel protocol, which does not require the use of unstable imine substrates, for the synthesis of allylamines, which are widely used in the production of fine chemicals, pharmaceuticals, and agrochemicals.

Nickel(0)-Catalyzed Hydroalkenylation of Imines with Styrene and Its Derivatives

A nickel(0)-catalyzed hydroalkenylation of imines with styrene and its derivatives is described. A wide range of aromatic and aliphatic imines directly coupled with styrene and its derivatives, thus providing various synthetically useful allylic amines with up to 95 % yield. The reaction offers a new atom- and step-economical approach to allylic amines by using alkenes instead of alkenyl-metallic reagents. Experiments and DFT calculations showed that TsNH2 promotes the proton transfer from the coordinated olefin to the imine, accompanied by a new C?C bond formation.

Preparation of azetidines by 4-endo trig cyclizations of N-cinnamyl tosylamides

Formation of azetidines by electrophilic cyclizations have been reported, starting with homoallylic amines (4-exo mode cyclizations). We reported that the formation of these compounds can be carried out starting with allylic amines (4-endo mode cyclizations) using bis(collidine)bromonium(I) hexafluorophosphate as an electrophile. These cyclizations occur via a carbocation intermediate.