61698-06-4Relevant academic research and scientific papers
Tris(trimethylsilyl)silane-mediated reductive decyanation and cyano transfer reactions of malononitriles
Kawamoto, Takuji,Shimaya, Yudai,Curran, Dennis P.,Kamimura, Akio
, p. 573 - 575 (2018)
Reductive decyanation reactions of malononitriles were achieved with tris(trimethylsilyl)silane as a radical mediator. The reaction proceeds via a radical chain mechanism involving a silyl radical addition to the malononitrile to form an imidoyl radical followed by α-cleavage to give a silyl isocyanide and an α-cyano radical. The reaction of a 3-butenyl-substituted malononitrile afforded a decyano/cyanosilylation product in good yield through 1,4-cyano transfer.
Synthesis of hexahydro[2]benzopyrano[4,3-c]pyridines as serotonin 5-HT 2C receptor agonists via intramolecular hetero Diels-Alder reactions
Kiyoi, Yasuko,Laats, Steven,Kiyoi, Takao,Wishart, Grant,Brown, Angus,Ray, Peter
scheme or table, p. 3417 - 3420 (2011/06/27)
Hexahydro[2]benzopyrano[4,3-c]pyridines were synthesized by an intramolecular hetero Diels-Alder reaction. The reaction was applicable to a range of substrates and the products could be easily converted into serotonin 5-HT2C receptor agonists.
Synthesis of hexahydro[2]benzopyrano[3,4-c]pyrroles as serotonin 5-HT 2C receptor agonists via intramolecular hetero Diels-Alder reactions
Kiyoi, Takao,Reid, Mark,Francis, Stuart,Davies, Keneth,Laats, Steven,McArthur, Duncan,Easson, Anna-Marie,Kiyoi, Yasuko,Tarver, Gary,Caulfield, Wilson,Gibson, Kirsty,Wishart, Grant,Morrison, Angus J.,Adam, Julia M.,Ray, Peter
scheme or table, p. 3413 - 3416 (2011/06/27)
[2]Benzopyrano[3,4-c]pyrroles were synthesized via an intramolecular hetero Diels-Alder reaction. The reaction was applicable to a wide range of substrates and the products could be easily converted into serotonin 5-HT2C receptor agonists.
BENZIMIDAZOLE OR INDOLE AMIDES AS INHIBITORS OF PIN1
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Page/Page column 128, (2010/11/08)
The invention relates to compounds of the formula (1) and to pharmaceutically acceptable salts and solvates thereof, wherein the variables are defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula (1) and to pharmaceutical compositions for treating such disorders that contain the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1).
Synthesis and evaluation of thiazole carboxamides as vanilloid receptor 1 (TRPV1) antagonists
Xi, Ning,Bo, Yunxin,Doherty, Elizabeth M.,Fotsch, Christopher,Gavva, Narender R.,Han, Nianhe,Hungate, Randall W.,Klionsky, Lana,Liu, Qingyian,Tamir, Rami,Xu, Shimin,Treanor, James J.S.,Norman, Mark H.
, p. 5211 - 5217 (2007/10/03)
A thiazole derivative, 2-(2,6-dichlorobenzyl)-N-(4-isopropylphenyl) thiazole-4-carboxamide (1), was identified as a TRPV1 antagonist. We synthesized various thiazole analogs and evaluated them for their ability to block capsaicin- or acid-induced calcium influx in TRPV1-expressing CHO cells. The IC50 values of the most potent antagonists were ca. 0.050 μM in these assays.
The novel preparation of hydrocinnamonitriles via the reduction of α- phenylsulfonyl cinnamonitriles with SmI2/CH3OH/THF system
Guo, Hongyun,Zhang, Yongmin
, p. 1879 - 1885 (2007/10/03)
Hydrocinnamonitriles were readily obtained via the reduction of α- phenylsulfonyl cinnamonitriles by SmI2/CH3OH/THF system.
BICYCLO (4.2.0) 1,3,5-OCTATRIENE COMPOUNDS AND USE AS ALPHA-ADRENERGICS
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, (2008/06/13)
Compounds of the formula: STR1 in which: R 1 and R 2 each represent, independently of one another, hydrogen, halogen, alkyl or alkoxy having from 1 to 4 carbon atoms, sulphonamide possibly substituted by an alkyl radical having from 1 to 4 carbon atoms; o
