306272-08-2

Upstream product

• 6311-60-0 3,5-dibromonitrobenzene 
• 1066-54-2 trimethylsilylacetylene 
• 5398-27-6 2,6-diiodo-4-nitroaniline 
• 57830-60-1 3,5-diiodonitrobenzene 

Downstream Products

• 1412499-30-9 (S)-di-tert-butyl (6-((3,5-bis((perfluoropyridin-4-yl)ethynyl)phenyl)amino)-6-oxohexane-1,5-diyl)dicarbamate 
• 1412499-29-6 3,5-bis((perfluoropyridin-4-yl)ethynyl)aniline 
• 1412499-28-5 4,4'-((5-nitro-1,3-phenylene)bis(ethyne-2,1-diyl))bis(2,3,5,6-tetrafluoropyridine) 
• 852944-51-5 1,3-bis([3-diethylamino-5-(trimethylsilylethynyl)phenyl]ethynyl)-5-nitrobenzene 
• 852944-52-6 1,3-bis[(3-diethylamino-5-ethynylphenyl)ethynyl]-5-nitrobenzene 
• 852944-48-0 3,5-bis[(3-amino-5-diethylaminophenyl)ethynyl]nitrobenzene 
• 852944-50-4 1,3-bis[(3-diethylamino-5-iodophenyl)ethynyl]-5-nitrobenzene 
• 756499-81-7 1,3-bis(ethynyl)-5-nitrobenzene 

Relevant academic research and scientific papers

Structures of N,N'-bis(1,2-dicarba-closo-dodecaboran-1-yl)-phenylureas: Building blocks for carborane-containing macromolecules

We report the preparation and structural analysis of carborane-containing diphenylureas (1a-c and 2a-c). The secondary ureas (1) exist in trans-conformation. In spite of the bulkiness of the carborane cage, the N-methylated ureas (2) exist in cis-conforma

Opening enediyne scissors wider: pH-dependent DNA photocleavage by meta-diyne lysine conjugates

Abstract Photochemical activation of meta-diynes incapable of Bergman and C1-C5 cyclizations still leads to efficient double-strand DNA cleavage. Spatial proximity of the two arylethynyl groups is not required for efficient DNA photocleavage by the enediyne-lysine conjugates. Efficiency of the cleavage is a function of the external pH and DNA damage is strongly enhanced at pH 7. The pH-dependence of the DNA photocleavage activity stems from the protonation states of lysine amino groups, the internal electron donors responsible for intramolecular PET quenching and deactivation of the photoreactive excited states. DNA-binding analysis suggests intercalative DNA binding for phenyl substituted conjugate and groove binding for TFP-substituted conjugate. Additional insights in the possible mechanism for DNA damage from the ROS (Reactive Oxygen Species) scavenger experiments found that generation of singlet oxygen is partially involved in the DNA damage. Upon photochemical activation, meta-bis-tetrafluoropyridinylalkyne-lysine conjugates induce pH-dependent DNA ds-photocleavage. Efficiency of DNA damage is strongly enhanced at pH 7. The observed pH-dependence of the DNA photocleavage activity stems from change in the protonation states of lysine amino groups. The ROS (Reactive Oxygen Species) scavenger experiments suggest that singlet oxygen is partially involved in the DNA damage.

Donor-acceptor-substituted phenylacetylene macrocycles with threefold symmetry

A stepwise synthesis of the donor-acceptor-substituted macrocycle 5,21,37-tris(diethylamino)-13,29,45-trinitro[2.2.2.2.2.2]metacyclophane-1,9,17, 25,33,42-hexayne (1a) from 3,5-bis(3-iodo-5-nitrophenylethynyl)-N,N- diethylaniline (11) and 3,5-bis([3-dieth

Synthesis of new diethynylbenzene derivatives

The preparation of new monomeric diacetylenic aromatic compounds is described.