306290-40-4

Upstream product

• 127-19-5 N,N-dimethyl acetamide 
• 131183-01-2 5-phenyl-2-((trimethylsilyl)methyl)-2H-tetrazole 
• 18039-42-4 5-Phenyl-1H-tetrazole 
• 78-95-5 chloroacetone 
• 18039-42-4 5-phenyl-2H-1,2,3,4-tetrazole 

Downstream Products

• 1617500-74-9 diethyl 2-hydroxy-1-(5-phenyl-2H-tetrazol-2-yl)-propan-2-ylphosphonate 
• 93742-44-0 (+/-)-1-(5-phenyl-2H-tetrazol-2-yl)propan-2-ol 

Relevant academic research and scientific papers

Reactions of 2-[lithio(trimethylsilyl)methyl]-2 H -tetrazoles: Synthesis of 2-[1-(trimethylsilyl)alkyl]-2 H -tetrazoles and (2 H -tetrazol-2-yl)acetates

The reaction of 2-[(trimethylsilyl)methyl]-2H-tetrazoles with various alkyl halides and carbonates using n-butyllithium or lithium diisopropylamide (LDA) gave 2-[1-(trimethylsilyl)alkyl]-2H-tetrazoles and (2H-tetrazol-2-yl)acetates as useful synthons of m

5-phenyl-2H-tetrazol-2-ylmethyl ketones in the synthesis of tetrazolylalkanols and tetrazolyl(hydroxy)alkylphosphonates

The reduction of 1-(5-phenyl-2H-tetrazol-2-yl)propan-2-one and 1-phenyl-2-(5-phenyl-2H-tetrazol-2-yl)ethanone with sodium tetrahydridoborate gave 1-(5-phenyl-2H-tetrazol-2-yl)propan-1-ol and 1-phenyl-2-(5-phenyl-2H- tetrazol-2-yl)ethanol, respectively. Only 1-(5-phenyl-2H-tetrazol-2-yl)propan-2- one was reduced with baker's yeast with an appreciable yield. 1-(5-Phenyl-2H-tetrazol-2-yl)propan-2-one and 1-phenyl-2-(5-phenyl-2H-tetrazol- 2-yl)ethanone reacted with diethyl phosphonate in the presence of potassium fluoride to produce the corresponding diethyl [hydroxy(5-phenyl-2H-tetrazol-2- yl)alkyl]phosphonates.

Lipase-catalyzed enantioseparation of alcohols containing a tetrazole ring

A simple chemoenzymatic method for the preparation of optically active (5-aryltetrazolyl-2)-4-butan-2-ol, (5-aryltetrazolyl-2)-propan-2-ol, and their acetates has been developed. The starting compounds (5-aryltetrazolyl-2)-4- butan-2-one and (5-aryltetraz