306296-71-9

Upstream product

• 75056-97-2 2,6-dimethyl-4-hydroxybenzoic acid 
• 75-65-0 tert-butyl alcohol 
• 7463-51-6 4-bromo-3,5-dimethylphenol 
• 95741-44-9 1-((4-bromo-3,5-dimethylphenoxy)methyl)benzene 
• 1361198-52-8 tert-butyl 4-(benzyloxy)-2,6-dimethylbenzoate 

Downstream Products

• 1426302-53-5 C₂₄H₃₁NO₅ 
• 1426302-54-6 C₃₁H₃₅NO₅ 
• 1426302-55-7 4-(4-((9H-fluoren-9-yl)methyl)-carbaminobutoxy)-2,6-dimethylbenzoic acid 
• 306296-75-3 2,6-dimethyl-4-trifluoromethanesulfonyloxy-benzoic acid tert-butyl ester 

Relevant academic research and scientific papers

Functionalizing αvβ3- or α5β1-selective integrin antagonists for surface coating: A method to discriminate integrin subtypes in vitro

Stuck with the right choice: αvβ3- or α5β1-selective integrin ligands were functionalized for surface coating without losing activity and selectivity. The coating of nanostructured gold surfaces with these compounds stimulated subtype-selective cell adhesion of genetically modified αvβ3- or α5β1-expressing fibroblasts in vitro. Copyright

Orally active β-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution

The effect of changing the C-4 substituent of 3,3-diethyl-1- [(benzylamino)carbonyl]-2-azetidinone on inhibition of HLE and in a model of HLE-induced lung damage in hamsters was explored. Substituents at this position do not appear to interact strongly with HLE with the most potent compounds having k(obs)/[I] = 6900 M-1 s-1. However, substituents at this position had a marked effect on in vivo activity. The greatest oral activity in the lung hemorrhage assay was achieved with C-4 aryl carboxylic acid ethers (60-85% inhibition at 30 mg/kg po). Based upon the established mechanism of inhibition by these compounds, the C-4 substituent would be released, and therefore, the pharmacological potential of these C-4 substituents was of considerable concern. Fortunately, compounds containing 4-hydroxybenzoic acid and 4-hydroxyphenylacetic acid ethers at C-4 were among the most active analogs. These phenolic acids are also found as urinary metabolites in healthy humans. Other heteroaryls at C-4 were also orally active in this model despite relatively modest enzyme activity.