95741-44-9Relevant articles and documents
Design, synthesis and evaluation of potent G-protein coupled receptor 40 agonists
Huang, Jing,Guo, Bin,Chu, Wen-Jing,Xie, Xin,Yang, Yu-She,Zhou, Xian-Li
supporting information, p. 159 - 162 (2016/01/26)
GPR40 has emerged as an attractive drug target for the treatment of type 2 diabetes due to its role in the enhancement of insulin secretion with glucose dependency. With the aim to improve the metabolic and safety profiles, a series of novel phenylpropionic acid derivatives were synthesized. Extensive structural optimization led to identification of compounds 22g and 23e as potent GPR40 agonists with moderate liver microsomal stability. All the discovery supported further exploration surrounding this scaffold.
Functionalizing αvβ3- or α5β1-selective integrin antagonists for surface coating: A method to discriminate integrin subtypes in vitro
Rechenmacher, Florian,Neubauer, Stefanie,Polleux, Julien,Mas-Moruno, Carlos,De Simone, Mariarosaria,Cavalcanti-Adam, Elisabetta Ada,Spatz, Joachim P.,F?ssler, Reinhard,Kessler, Horst
supporting information, p. 1572 - 1575 (2013/04/10)
Stuck with the right choice: αvβ3- or α5β1-selective integrin ligands were functionalized for surface coating without losing activity and selectivity. The coating of nanostructured gold surfaces with these compounds stimulated subtype-selective cell adhesion of genetically modified αvβ3- or α5β1-expressing fibroblasts in vitro. Copyright
AMINOPHENYLPROPANOIC ACID DERIVATIVE
-
Page/Page column 117, (2010/11/24)
A compound represented by the formula (1): wherein each symbol is as defined in the specification, and a salt thereof and a prodrug thereof unexpectedly have superior GPR40 receptor agonist activity, superior in the properties as a pharmaceutical product such as stability and the like, and can be a safe and useful pharmaceutical agent as a drug for the prophylaxis or treatment of GPR40 receptor related pathology or diseases such as diabetes and the like.