306297-02-9Relevant academic research and scientific papers
PIPERAZINE DERIVATIVES USEFUL AS CCR5 ANTAGONISTS
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Page/Page column 27, (2010/02/12)
The use is described of CCR5 antagonists of formula (I) or a pharmaceutically acceptable salt thereof, wherein: R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R 1 is hydrogen or alkyl; R 2 is substituted phenyl, substituted heteroary
Piperazine derivatives useful as CCR5 antagonists
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Page column 41, (2010/02/05)
The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1is hydrogen or alkyl; R2is substituted phenyl, substituted heter
QSAR studies on 2-(benzyl)imidazoline analogs as h5-HT1D/1B serotonin receptor ligands
Prisinzano,Law,Slassi,Maclean,Demchyshyn,Glennon
, p. 309 - 317 (2007/10/03)
Human 5-HT1D/1B receptors are the likely therapeutic targets of several clinically used migraine-abortive triptans such as sumatriptan. The present investigation, using several QSAR methods (e.g. CoMFA and Hansch analysis), attempts to better explain the structure-affinity relationships of 2-(benzyl)imidazolines and benzylimidazoline-related compounds for binding at h5-HT1D receptors. It was found that lipophilicity at the 4-position of benzylimidazolines correlates well both with h5-HT1D and h5-HT1B receptor affinity.
