306763-43-9Relevant articles and documents
Chemoenzymatic synthesis of enantiomerically pure 1,2-diols employing immobilized lipase in the ionic liquid [bmim]PF6
Kamal, Ahmed,Chouhan, Gagan
, p. 8801 - 8805 (2007/10/03)
Significantly enhanced enantioselectivity in the enzymatic kinetic resolution of 1,2-diols employing immobilized lipase from Pseudomonas cepacia (PS-C, 'Amano') results from the use of the ionic liquid [bmim]PF6 as reaction medium.
Chemoenzymatic synthesis of enantiomerically pure terminal 1,2-diols
Kamal, Ahmed,Sandbhor, Mahendra,Ahmed, Kaleem,Adil,Shaik, Ahmad Ali
, p. 3861 - 3866 (2007/10/03)
A new practical method for the enzymatic synthesis of 1,2-diols has been developed by employing a lipase catalyzed one-pot transesterification protocol. A series of substituted α-acetoxyphenylethanones 3a-g have been reduced to the corresponding alcohols under mild conditions employing sodium borohydride and moist neutral alumina, and further subjected for lipase catalyzed irreversible transesterification in the same pot to give mono- and diacetate diols (R)-4 and (S)-5, which on hydrolysis afforded terminal 1,2-diols, (R)- and (S)-6 in high enantiomeric excess.
Baker's yeast-mediated reduction of α-hydroxy ketones and derivatives: The steric course of the biotransformation
Ferraboschi, Patrizia,Grisenti, Paride,Manzocchi, Ada,Santaniello, Enzo
, p. 10539 - 10548 (2007/10/02)
The results from the baker's yeast-mediated reduction of the acetates 3a- d and the methyl ethers 5a-d were compared with the same biotransformation which converts the α-hydroxy ketones 1a-d into the (R)-diols 2a-d (90- 98%ee); the acetates 3a-d afford the (S)-monoacetates 4a-d (72-94% ee) and the methyl ethers 5a-d are reduced to the (R)-monoethers 6a-d (64-76% ee).
