306934-78-1

Basic information

• Product Name: 4-CHLORO-5-METHYL-6-PHENYLTHIENO[2,3-D]PYRIMIDINE
• Synonyms: 4-CHLORO-5-METHYL-6-PHENYLTHIENO[2,3-D]PYRIMIDINE;4-CHLORO-5-METHYL-6-PHENYLTHIENO[2,3-D]P;4-Chloro-5-methyl-6-phenylthieno[2,3-d]pyrimidine97%
• CAS NO: 306934-78-1
• Molecular Formula: C₁₃H₉ClN₂S
• Molecular Weight: 260.74
• Mol File: 306934-78-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 131-132
• Boiling Point: 407.1°Cat760mmHg
• Flash Point: 200°C
• Appearance: /
• Density: 1.351g/cm³
• Vapor Pressure: 1.82E-06mmHg at 25°C
• Refractive Index: 1.68
• PKA: 0.59±0.40(Predicted)
• CAS DataBase Reference: 4-CHLORO-5-METHYL-6-PHENYLTHIENO[2,3-D]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-5-METHYL-6-PHENYLTHIENO[2,3-D]PYRIMIDINE(306934-78-1)
• EPA Substance Registry System: 4-CHLORO-5-METHYL-6-PHENYLTHIENO[2,3-D]PYRIMIDINE(306934-78-1)

Safety Data

• Hazard Codes: Xi
• Safety Statements: S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 306934-78-1(Hazardous Substances Data)

Usage

General Description

4-CHLORO-5-METHYL-6-PHENYLTHIENO[2,3-D]PYRIMIDINE is a chemical compound with the molecular formula C12H8ClN3S. It is a heterocyclic compound containing a thiophene ring fused to a pyrimidine ring, with a chloro and a methyl group at specific positions, as well as a phenyl ring attached to the pyrimidine. 4-CHLORO-5-METHYL-6-PHENYLTHIENO[2,3-D]PYRIMIDINE has potential applications in pharmaceutical research and development, particularly in the synthesis of novel drug candidates and bioactive molecules. Its unique structure and properties make it of interest to medicinal chemists and organic chemists for its potential biological activities and therapeutic uses. Further research and investigations into the biological activities and potential applications of 4-CHLORO-5-METHYL-6-PHENYLTHIENO[2,3-D]PYRIMIDINE are warranted to fully understand its potential in drug discovery and development.

InChI:InChI=1/C13H9ClN2S/c1-8-10-12(14)15-7-16-13(10)17-11(8)9-5-3-2-4-6-9/h2-7H,1H3

Upstream product

• 306934-76-9 5-methyl-6-phenylthieno[2,3-d]pyrimidin-4(3H)-one 
• 4815-39-8 2-amino-4-methyl-5-phenyl-thiophen-3-carboxamide 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 1101198-31-5 4-(2-hydroxyethylamino)-5-methyl-6-phenylthieno[2,3-d]pyrimidine 
• 1101198-29-1 4-diethylamino-5-methyl-6-phenylthieno[2,3-d]pyrimidine 
• 1234360-69-0 4-ethoxy-5-methyl-6-phenylthieno[2,3-d]pyrimidine 
• 1007798-19-7 4-ethylamino-5-methyl-6-phenylthieno[2,3-d]pyrimidine 

Relevant articles and documents

Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase

The human farnesyl pyrophosphate synthase (hFPPS), a key regulatory enzyme in the mevalonate pathway, catalyzes the biosynthesis of the C-15 isoprenoid farnesyl pyrophosphate (FPP). FPP plays a crucial role in the post-translational prenylation of small GTPases that perform a plethora of cellular functions. Although hFPPS is a well-established therapeutic target for lytic bone diseases, the currently available bisphosphonate drugs exhibit poor cellular uptake and distribution into nonskeletal tissues. Recent drug discovery efforts have focused primarily on allosteric inhibition of hFPPS and the discovery of non-bisphosphonate drugs for potentially treating nonskeletal diseases. Hit-to-lead optimization of a new series of thienopyrimidine-based monosphosphonates (ThP-MPs) led to the identification of analogs with nanomolar potency in inhibiting hFPPS. Their interactions with the allosteric pocket of the enzyme were characterized by crystallography, and the results provide further insight into the pharmacophore requirements for allosteric inhibition.

Thieno[2,3-d]pyrimidines as antagonists of the glutamate receptors

Although the function of the kainate receptors in the brain is still not clear, they are increasingly defined as targets in the development of new classes of anti-epileptics. The thienopyrimidines described in this report were tested for their antagonisti