306934-98-5 Usage
Uses
Used in Pharmaceutical Synthesis:
2-(2-Thienyl)-1,3-thiazole-4-carbonyl chloride is used as a precursor in the synthesis of various pharmaceuticals. Its reactivity with amines and other nucleophiles allows for the formation of thiazole and thiol compounds, which are important in the development of new drugs.
Used in Agrochemical Synthesis:
In the agrochemical industry, 2-(2-Thienyl)-1,3-thiazole-4-carbonyl chloride serves as a key intermediate for the production of various agrochemicals. Its ability to react with different nucleophiles contributes to the creation of compounds with potential applications in crop protection and pest control.
Used in Organic Synthesis:
2-(2-Thienyl)-1,3-thiazole-4-carbonyl chloride is used as a versatile intermediate in organic synthesis. Its carbonyl chloride group enables the formation of amides and esters, expanding its potential applications in the synthesis of a wide range of organic compounds.
Overall, 2-(2-Thienyl)-1,3-thiazole-4-carbonyl chloride is a valuable chemical compound with diverse applications across various industries, including pharmaceuticals, agrochemicals, and organic synthesis, due to its unique structure and reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 306934-98-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,6,9,3 and 4 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 306934-98:
(8*3)+(7*0)+(6*6)+(5*9)+(4*3)+(3*4)+(2*9)+(1*8)=155
155 % 10 = 5
So 306934-98-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H4ClNOS2/c9-7(11)5-4-13-8(10-5)6-2-1-3-12-6/h1-4H
306934-98-5Relevant academic research and scientific papers
PHARMACEUTICALLY ACTIVE BENZOXAZOLE, BENZTHIAZOLE AND BENZIMIDAZOLE ACID DERIVATIVES
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Page 29, (2010/02/07)
Compounds of formula (I): wherein R1, R2 and R3 are independently, hydrogen, halogen, CF3, OR6, NR7R8, NR8COR10, NR8SO2R10 or C1-6 alkyl optionally substituted by hydroxy, C1-6 alkoxy or NR7R8; R4 is NR8CONR8R9, NR8COR9, NR8SO2R9, or W-CONR8R9, where W is a bond, C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene; and R5 is Formula (A) methods for their synthesis, pharmaceutical compositions comprising them and their use in medicine, in particular for the treatment of cancer.
A catch-and-release strategy for the combinatorial synthesis of 4-acylamino-1,3-thiazoles as potential CDK5 inhibitors
Larsen, Scott D.,Stachew, Carl F.,Clare, Paula M.,Cubbage, Jerry W.,Leach, Karen L.
, p. 3491 - 3495 (2007/10/03)
Two-dimensional libraries of 4-acylamino-1,3-thiazoles 9 were prepared via Curtius rearrangement of 1,3-thiazole-4-carbonyl azides 6, trapping of the intermediate isocyanates with oxime resin, and thermal regeneration of the isocyanates from the washed resin in the presence of nucleophiles. Several compounds proved to be selective inhibitors of CDK5/p25 versus the closely homologous CDK2/cyclin A enzyme, with the best analogue (43) possessing over 100-fold selectivity.
