24043-97-8

Usage

Uses

Used in Medical Research:
ETHYL 2-(2-THIENYL)-1,3-THIAZOLE-4-CARBOXYLATE is used as a research compound for exploring its potential applications in the development of new pharmaceuticals. Its unique structure may offer novel interactions with biological targets, leading to the discovery of new therapeutic agents.
Used in Agricultural Research:
In the agricultural industry, ETHYL 2-(2-THIENYL)-1,3-THIAZOLE-4-CARBOXYLATE is used as a research compound to investigate its potential as a pesticide or herbicide. Its chemical properties may provide new ways to control pests and weeds, contributing to more effective and sustainable agricultural practices.
Used in Industrial Research:
ETHYL 2-(2-THIENYL)-1,3-THIAZOLE-4-CARBOXYLATE is used as a research compound in the industrial sector to explore its potential applications in the development of new materials and chemical processes. Its unique structure may contribute to the creation of innovative products and technologies with improved performance and efficiency.

InChI:InChI=1/C10H9NO2S2/c1-2-13-10(12)7-6-15-9(11-7)8-4-3-5-14-8/h3-6H,2H2,1H3

Upstream product

• 20300-02-1 thiophene-2-carbothioamide 
• 673476-96-5 (2-chloro-phenyl)-thioacetic acid amide 
• 5813-89-8 2-thiophenylcarboxamide 
• 70-23-5 ethyl Bromopyruvate 
• 98-03-3 thiophene-2-carbaldehyde 
• 868-59-7 L-cysteine ethyl ester hydrochloride 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 34034-87-2 diethyl 3-chloro-2-oxosuccinate 
• 14037-19-5 2-thiophen-2-yl-thiazole-4,5-dicarboxylic acid diethyl ester 
• 24044-03-9 2-thiophen-2-yl-thiazole-4,5-dicarboxylic acid 4-ethyl ester 

Downstream Products

• 154323-99-6 2-(2-thienyl)-4-thiazolecarbohydrazide 
• 54986-94-6 (2-thiophen-2-ylthiazole-4-yl)methanol 
• 306934-98-5 2-(2-thienyl)-4-thiazolecarboxylic acid chloride 
• 24044-07-3 2-thiophen-2-yl-thiazole-4-carboxylic acid 

Relevant academic research and scientific papers

I2/TBHP-Mediated tandem cyclization and oxidation reaction: Facile access to 2-substituted thiazoles and benzothiazoles

The efficient synthesis of 2-substituted thiazoles and benzothiazoles has been accomplished employing readily available cysteine esters and 2-aminobenzenethiols as N and S sources. The reaction proceeds under an I2/TBHP system and involves a on

A concise and efficient route to the total synthesis of bacillamide A and its analogues

The synthesis of bacillamide A, a tryptamide alkaloid of marine origin, and its analogues from L-cysteine ethyl ester hydrochloride through an efficient and convergent synthetic approach is described in this work. The present two-step protocol involves th

Solvent-free synthesis of bacillamide analogues as novel cytotoxic and anti-inflammatory agents

Synthesis of fourteen analogues of bacillamide, a bioactive tryptamide alkaloid of marine origin, has been accomplished through a highly efficient convergent route. The present solvent-free protocol involves the formation of thiazole ring in the initial step followed by amide coupling between substituted ethyl 2-alkyl/aryl/heteroaryl/amino/aminoarylthiazole-4-carboxylates and tryptamine in presence of 2-hydroxy-4,6-dimethylpyrimidine, a solid phase catalyst to yield N-[2-(1H-indol-3-yl)ethyl]-2-alkyl/aryl/heteroaryl/amino/aminoarylthiazole-4-carboxamides as bacillamide analogues having structural variation at position-2 of thiazole ring. Bacillamide and its analogues were evaluated for their cytotoxic activity against three cancer cell lines (HCT-116, MDA-MD-231 and JURKAT cell lines) using colorimetric cell proliferation assay. Compounds 17a and 17b exhibited potent anti-cell proliferation activity with IC50values in the range of ～3.0?μM and ～0.1–0.6?μM, respectively against these cell lines. Preliminary mechanism of action studies indicates that these compounds initiate caspase dependent apoptosis. Also, compounds 16d, 16f, 17a and 17d exhibited excellent anti-inflammatory activity comparable to well-known NSAID indomethacin and better to bacillamide, when evaluated using carrageenan induced rat hind paw oedema method.

THIAZOLE COMPOUND AND PREPARATION METHOD AND USE THEREOF

The present invention relates to thiazole compounds of formula I , the method for preparation and use thereof. More specifically, the present invention relates to novel derivatives of natural product largazole, the method for preparing them and their uses

THIAZOLE COMPOUNDS, METHODS FOR PREPARATION AND USE THEREOF

The present invention relates to thiazole compounds of formula I, the method for preparation and use thereof. More specifically, the present invention relates to novel derivatives of natural product largazole, the method for preparing them and their uses

A catch-and-release strategy for the combinatorial synthesis of 4-acylamino-1,3-thiazoles as potential CDK5 inhibitors

Two-dimensional libraries of 4-acylamino-1,3-thiazoles 9 were prepared via Curtius rearrangement of 1,3-thiazole-4-carbonyl azides 6, trapping of the intermediate isocyanates with oxime resin, and thermal regeneration of the isocyanates from the washed resin in the presence of nucleophiles. Several compounds proved to be selective inhibitors of CDK5/p25 versus the closely homologous CDK2/cyclin A enzyme, with the best analogue (43) possessing over 100-fold selectivity.