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(E)-4-((4-phenylpiperazin-1-ylimino)methyl)benzene-1,3-diol, also known as G-1, is a synthetic compound that has been studied for its potential therapeutic effects. It is a selective agonist for the G protein-coupled estrogen receptor 1 (GPER1), also known as GPR30, and has been investigated for its potential use in hormone-related diseases such as breast cancer and osteoporosis. G-1 has shown promising results in preclinical studies, demonstrating its ability to modulate estrogen signaling and exert both anti-proliferative and anti-inflammatory effects. Its unique mechanism of action and potential therapeutic applications make G-1 an interesting candidate for further research and development in the field of drug discovery.

306953-58-2

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306953-58-2 Usage

Uses

Used in Pharmaceutical Industry:
(E)-4-((4-phenylpiperazin-1-ylimino)methyl)benzene-1,3-diol is used as a therapeutic agent for hormone-related diseases such as breast cancer and osteoporosis. Its agonistic action on GPER1 modulates estrogen signaling, leading to anti-proliferative and anti-inflammatory effects, which can be beneficial in the treatment and management of these conditions.
Used in Drug Discovery Research:
(E)-4-((4-phenylpiperazin-1-ylimino)methyl)benzene-1,3-diol is used as a research compound for exploring its potential in the development of new drugs targeting hormone-related diseases. Its unique mechanism of action and the promising results from preclinical studies make it a valuable candidate for further investigation in the field of drug discovery.

Check Digit Verification of cas no

The CAS Registry Mumber 306953-58-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,6,9,5 and 3 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 306953-58:
(8*3)+(7*0)+(6*6)+(5*9)+(4*5)+(3*3)+(2*5)+(1*8)=152
152 % 10 = 2
So 306953-58-2 is a valid CAS Registry Number.

306953-58-2Downstream Products

306953-58-2Relevant academic research and scientific papers

Structure-activity studies in the development of a hydrazone based inhibitor of adipose-triglyceride lipase (ATGL)

Mayer, Nicole,Schweiger, Martina,Melcher, Michaela-Christina,Fledelius, Christian,Zechner, Rudolf,Zimmermann, Robert,Breinbauer, Rolf

, p. 2904 - 2916 (2015)

Adipose triglyceride lipase (ATGL) catalyzes the degradation of cellular triacylglycerol stores and strongly determines the concentration of circulating fatty acids (FAs). High serum FA levels are causally linked to the development of insulin resistance a

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