14340-32-0

Basic information

• Product Name: 1-Piperazinamine,4-phenyl-(9CI)
• Synonyms: 1-Piperazinamine,4-phenyl-(9CI);4-PHENYLPIPERAZIN-1-AMINE;(4-Phenylpiperazin-1-yl)amine;1-Amino-4-phenylpiperazine;4-Phenyl-1-piperazinamine
• CAS NO: 14340-32-0
• Molecular Formula: C₁₀H₁₅N₃
• Molecular Weight: 177.25
• Product Categories: PIPERIDINE
• Mol File: 14340-32-0.mol

Chemical Properties

• Appearance: /
• Density: 1.105
• CAS DataBase Reference: 1-Piperazinamine,4-phenyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinamine,4-phenyl-(9CI)(14340-32-0)
• EPA Substance Registry System: 1-Piperazinamine,4-phenyl-(9CI)(14340-32-0)

Safety Data

• Hazardous Substances Data: 14340-32-0(Hazardous Substances Data)

Usage

Type of compound

Phenylpiperazine derivative

Usage

Precursor in the synthesis of pharmaceuticals and research chemicals

Applications

Production of antipsychotic and antihistamine drugs, development of novel therapeutic agents

Potential therapeutic benefits

Serotonin antagonist, treatment of anxiety disorders and other mental health conditions

Interest

Researchers and pharmaceutical companies for its potential therapeutic benefits.

Upstream product

• 14340-33-1 1-nitroso-4-phenylpiperazine 
• 92-54-6 4-phenyl-1-piperazine 

Downstream Products

• 306953-58-2 (E)-4-((4-phenylpiperazin-1-ylimino)methyl)benzene-1,3-diol 

Relevant articles and documents

Selective reduction of N-nitroso aza-aliphatic cyclic compounds to the corresponding N-amino products using zinc dust in CO2–H2O medium

[Figure not available: see fulltext.] A new method for reduction of N-nitroso aza-aliphatic cyclic compounds employing zinc in pressurized CO2–H2O medium has been developed. H2O and NH4Cl were used as hydrogen donors, and reduction was performed under environmentally benign conditions. The presented approach allowed to obtain the respective N-amino products selectively and in excellent yields (up to 97%).

Structure-activity studies in the development of a hydrazone based inhibitor of adipose-triglyceride lipase (ATGL)

Adipose triglyceride lipase (ATGL) catalyzes the degradation of cellular triacylglycerol stores and strongly determines the concentration of circulating fatty acids (FAs). High serum FA levels are causally linked to the development of insulin resistance a

NEW DRUGS WITH ANTICHOLESTATIC ACTIVITY

New compounds belonging to the structural formula (I) are described. formula (I) in which R1, R2, A, Y and X are specified in the description, useful in the treatment of cholestasis and substantially devoid of antibacterial activity. The synthesis process of said compounds, the pharmaceutical compositions containing them and their use in therapy are also described.

SYNTHESIS OF 4-METHOXYPHENOXYACETIC AND 3,4,5-TRIMETHOXYPHENOXYACETIC ACID AMIDES AND HYDRAZIDES AS POTENTIAL NEUROTROPIC AND CARDIOVASCULAR AGENTS

4-Methoxyphenoxyacetyl chloride, 3,4,5-trimethoxyphenoxyacetic acid and its methyl ester were reacted with 2-phenylethylamine, 1-benzylpiperazine, 1-(2-phenylethyl)piperazine, 1-(1-phenyl-2-propyl)piperazine, isopropylhydrazine, 1-aminopiperidine, and 4-aminomorpholine and afforded the amides and hydrazides Iab-IVab and Vb-VIIIb. 1-Amino-4-methylpiperazine and 1-amino-4-phenylpiperazine were transformed to the hydrazones XV and XVI, and to the quaternary salts XVII and XVIII.Pharmacological screening showed indications of thymoleptic acitivity with compounds Ia-IIIa, anorectic effect with IIa and IIIb, antiarrhytmic activity with IIIa, XVII, and XVIII, and myorelaxant effect with XVII and XVIII.Antimicrobial and anthelmintic effects were also noted.