307002-73-9 Usage
Uses
WAY 170523 is a matrix metalloproteinase inhibitor.
Biological Activity
Potent and selective inhibitor of MMP-13 (IC 50 values are 17, 945, > 1000 and > 10000 nM for MMP-13, MMP-9, TACE and MMP-1 respectively).
Check Digit Verification of cas no
The CAS Registry Mumber 307002-73-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,7,0,0 and 2 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 307002-73:
(8*3)+(7*0)+(6*7)+(5*0)+(4*0)+(3*2)+(2*7)+(1*3)=89
89 % 10 = 9
So 307002-73-9 is a valid CAS Registry Number.
InChI:InChI=1/C33H31N3O7S/c1-22-18-23(2)31(28(19-22)32(37)35-39)36(21-24-8-4-3-5-9-24)44(40,41)27-14-12-26(13-15-27)42-17-16-34-33(38)30-20-25-10-6-7-11-29(25)43-30/h3-15,18-20,39H,16-17,21H2,1-2H3,(H,34,38)(H,35,37)
307002-73-9Relevant academic research and scientific papers
Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase inhibitors
-
, (2008/06/13)
Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs.
Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design
Chen,Nelson,Levin,Mobilio,Moy,Nilakantan,Zask,Powers
, p. 9648 - 9654 (2007/10/03)
The high-resolution NMR solution structure of the catalytic fragment of human collagenase-3 (MMP-13) was used as a starting point for structure-based design of selective inhibitors for MMP-13. The major structural difference observed between the MMP struc
