30727-24-3

Basic information

• Product Name: (±)-1-methylpyrrolidine-2-methanol
• Synonyms: (±)-1-Methylpyrrolidine-2-methanol;(1-Methylpyrrolidin-2-yl)methanol
• CAS NO: 30727-24-3
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.17352
• EINECS: 250-312-8
• Mol File: 30727-24-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 164.8 °C at 760 mmHg
• Flash Point: 63.3 °C
• Appearance: /
• Density: 0.973 g/cm³
• Vapor Pressure: 0.649mmHg at 25°C
• Refractive Index: 1.468
• CAS DataBase Reference: (±)-1-methylpyrrolidine-2-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (±)-1-methylpyrrolidine-2-methanol(30727-24-3)
• EPA Substance Registry System: (±)-1-methylpyrrolidine-2-methanol(30727-24-3)

Safety Data

• Hazardous Substances Data: 30727-24-3(Hazardous Substances Data)

Usage

General Description

(±)-1-methylpyrrolidine-2-methanol is a chemical compound that consists of a pyrrolidine ring with a methyl group and a hydroxyl group attached to it. It is a chiral compound, meaning it exists in both a left-handed and right-handed form. (±)-1-methylpyrrolidine-2-methanol has applications in the pharmaceutical industry, where it can be used as a building block for the synthesis of various drug molecules. It can also be used as a chiral auxiliary in asymmetric synthesis reactions. Additionally, it is used in the production of agrochemicals and in the development of new materials with unique properties. The compound has the potential for various industrial and medical applications due to its unique structure and properties.

InChI:InChI=1/C6H13NO/c1-7-4-2-3-6(7)5-8/h6,8H,2-5H2,1H3

Upstream product

• 68078-09-1 N-methylproline 
• 68832-13-3 D-prolinol 
• 59378-81-3 1-(tert-butoxycarbonyl)prolin-2R-ol 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 
• 895160-34-6 (R)-pyrrolidine-1,2-dicarboxylic acid 2-tert-butyl ester 1-ethyl ester 
• 265660-44-4 (2S)-(+)-N-methyl-2-tributylstannylpyrrolidine 
• 344-25-2 D-Prolin 
• 74-88-4 methyl iodide 
• 175725-27-6 (R)-1-ethoxycarbonylprolin 
• 475-11-6 N-methyl-D-proline 

Downstream Products

• 909783-58-0 (R)-2-(2-Methoxy-4-nitro-phenoxymethyl)-1-methyl-pyrrolidine 
• 1397922-62-1 (E)-N-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolyl]-3-[(2R)-1-methylpyrrolidin-2-yl]prop-2-enamide L-malate 
• 1397922-61-0 (E)-N-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolyl]-3-[(2R)-1-methylpyrrolidin-2-yl]prop-2-enamide maleate 
• 1397922-61-0 (R,E)-N-(4-(3-chloro-4-(pyridine-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinoline-6-yl)-3-(1-methylpyrrolidinyl-2-yl)acrylamide dimaleate salt 
• 1428555-18-3 C₂₁H₂₄BrF₃N₂O₅S 
• 1428555-25-2 C₁₃H₁₅F₃N₂O₃ 

Relevant articles and documents

Search for Configurationally Stable, Aracemic α-Amino Organolithiums

The search for configurationally stable α-amino carbanions has led to an interesting observation of differing reactivity of diastereomeric organolithiums and to the characterization of aracemic 2-lithio-N-methylpiperidine and 2-lithio-N-methylpyrrolidine as configurationally stable α-aminoorganolithiums.Details for the preparation of these and related α-lithioheterocycles, evaluation of their and configurational stability, and a preliminary evaluation of the stereoselevtivity of their reactions with electrophiles is presented. - Keywords: α-Amino organolithiums; α-amino carbaions; 2-lithiopiperidine; 2-lithiopyrrrolidine; configurationally stable carbanions.

6-AMINO QUINAZOLINE OR 3-CYANO QUINOLINE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF

The present disclosure relates to 6-amino quinazoline or 3-cyano quinoline derivatives, preparation processes and pharmaceutical compositions containing them. Specifically, the present disclosure relates to novel 6-amino quinazoline or 3-cyano quinoline derivatives presented by formula (I), or its tautomer, enantiomer, diastereomer, racemate or pharmaceutically acceptable salts thereof, or metabolite, metabolic precursor or prodrug thereof, and the uses for treatment especially for protein kinase inhibitors, in which each substitute group of general formula (I) is as defined in the specification.

PHARMACEUTICALLY ACCEPTABLE SALT OF (E)-N-[4-[[3-CHLORO-4-(2-PYRIDYLMETHOXY)PHENYL]AMINO]-3-CYANO-7-ETHOXY-6-QUINOLYL]-3-[(2R)-1-METHYLPYRROLIDIN-2-YL]PROP-2-ENAMIDE, PREPARATION METHOD THEREOF, AND MEDICAL USE THEREOF

Provided as represented by formula (I) is a pharmaceutically acceptable salt of (E)-N-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolyl]-3-[(2R)-1-methylpyrrolidin-2-yl]prop-2-enamide, a preparation method thereof, and a use thereof as a therapeutic agent, and especially as a protein kinase inhibitor.