68078-09-1

Basic information

• Product Name: 1-Methylpyrrolidine-2-carboxylic acid
• Synonyms: 1-Methylpyrrolidine-2-carboxylic acid;1-methylproline(SALTDATA: HCl);proline, 1-methyl-;N-methyl DL-proline;DL-Proline, 1-methyl-;1-Methyl-DL-proline
• CAS NO: 68078-09-1
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.15704
• Mol File: 68078-09-1.mol
• Article Data: 49

Chemical Properties

• Melting Point: 116 °C
• Boiling Point: 227.1 °C at 760 mmHg
• Flash Point: 91.1 °C
• Appearance: /
• Density: 1.153 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.37±0.20(Predicted)
• CAS DataBase Reference: 1-Methylpyrrolidine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methylpyrrolidine-2-carboxylic acid(68078-09-1)
• EPA Substance Registry System: 1-Methylpyrrolidine-2-carboxylic acid(68078-09-1)

Safety Data

• Hazardous Substances Data: 68078-09-1(Hazardous Substances Data)

Usage

General Description

1-Methylpyrrolidine-2-carboxylic acid, also known as N-Methylproline, is an organic compound that falls into the category of pyrrolidines. It is structurally and chemically similar to proline, an amino acid. It is generally used in a variety of chemiсal reactions due to its reactivity and steric interplay. In medicinal chemistry, it has been shown to be a beneficial molecular scaffold because of its rigidity and potential ability to construct constrained amino acid derivatives. Its potential applications are in peptide synthesis and pharmaceutical research. Safety information on this compound is limited and thus it must be handled with care.

InChI:InChI=1S/C6H11NO2/c1-7-4-2-3-5(7)6(8)9/h5H,2-4H2,1H3,(H,8,9)

Upstream product

• 56-81-5 glycerol 
• 120-94-5 1-Methylpyrrolidine 
• 124-38-9 carbon dioxide 
• 50-00-0 formaldehyd 
• 147-85-3 L-proline 
• 265660-44-4 (2S)-(+)-N-methyl-2-tributylstannylpyrrolidine 
• 104097-12-3 1-methyl-3-(1-methyl-pyrrolidin-2-yl)-1H-pyridin-2-one 
• 7664-93-9 sulfuric acid 
• 67-56-1 methanol 
• 344-25-2 D-Prolin 
• 471-87-4 L-proline betaine 
• 7776-34-3 L-proline hydrochloride 

Downstream Products

• 471-87-4 L-proline betaine 
• 30727-23-2 1-methyl-DL-prolin-ethyl ester 
• 3554-65-2 (R)-N-methylpyrrolidine-2-methanol 
• 34381-71-0 (S)-2-hydroxymethyl-1-methylpyrrolidine 
• 345583-03-1 (2S)-N-{3-Chloro-4-[4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidin-1-yl]phenyl}-1-methylpyrrolidine-2-carboxamide 
• 1095322-95-4 N-[1-(1-methyl-L-prolyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide hydrochloride 

Relevant articles and documents

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