307313-06-0

Basic information

• Product Name: Pyrazolo[1,5-a]pyridine-2-carboxaldehyde, 4,5,6,7-tetrahydro- (9CI)
• Synonyms: Pyrazolo[1,5-a]pyridine-2-carboxaldehyde, 4,5,6,7-tetrahydro- (9CI);4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carbaldehyde;4,5,6,7-Tetrahydropyrazolo[1,5-a]pyridine-2-carboxaldehyde
• CAS NO: 307313-06-0
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.1778
• Product Categories: ALDEHYDE
• Mol File: 307313-06-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 321.356 °C at 760 mmHg
• Flash Point: 148.151 °C
• Appearance: /
• Density: 1.284 g/cm³
• PKA: 0.59±0.20(Predicted)
• CAS DataBase Reference: Pyrazolo[1,5-a]pyridine-2-carboxaldehyde, 4,5,6,7-tetrahydro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazolo[1,5-a]pyridine-2-carboxaldehyde, 4,5,6,7-tetrahydro- (9CI)(307313-06-0)
• EPA Substance Registry System: Pyrazolo[1,5-a]pyridine-2-carboxaldehyde, 4,5,6,7-tetrahydro- (9CI)(307313-06-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 307313-06-0(Hazardous Substances Data)

Usage

General Description

Pyrazolo[1,5-a]pyridine-2-carboxaldehyde, 4,5,6,7-tetrahydro- (9CI) is a chemical compound with a complex and specific structure. It is a heterocyclic compound that contains both pyrazole and pyridine rings, as well as a carboxaldehyde group. The tetrahydro- prefix indicates that the compound has four hydrogen atoms added to the structure. This chemical compound has potential applications in the pharmaceutical industry, particularly in the development of new drugs and bioactive molecules. Its unique structure and properties make it an interesting target for further research and potential use in medical or scientific applications.

Upstream product

• 623564-49-8 (4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-2-yl)methanol 
• 307307-84-2 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylic acid ethyl ester 
• 105786-95-6 4,5,6,7-tetrahydro<1.2.3>oxadiazolo<3,4-a>pyridin-3-one 
• 4515-18-8 1-nitroso-piperidine-2-carboxylic acid 
• 4043-87-2 pipecolic Acid 
• 1052103-62-4 1-[4-(phenylselanyl)butyl]-1H-pyrazole-3-carbaldehyde 

Downstream Products

• 1025959-41-4 6-[acetoxy-(4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyridin-2-yl)-methyl]-6-bromo-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 

Relevant articles and documents

Bu3SnH-mediated radical cyclisation onto azoles

Alkyl radicals have been cyclised onto pyrroles, imidazoles and pyrazoles, and acyl radicals cyclised onto pyrroles, using Bu3SnH-, (TMS)3SiH- and Bu3GeH-mediated aromatic homolytic substitution for the synthesis of bicyclic N-heterocycles. The reactions yield intermediate π-radicals that lose hydrogen in the?rearomatisation step of the aromatic homolytic substitution. Mechanistic studies of these rearomatisation steps indicate aromatic homolytic substitution in which the initiator or breakdown products from the inhibitor are responsible for the H-abstraction step.

Bicyclic 6-alkylidene-penems as class-D beta-lactamases inhibitors

This invention relates to certain bicyclic 6-alkylidene penems which act as a inhibitor of class-D enzymes. β-Lactamases hydrolyze β-lactam antibiotics, and as such serve as the primary cause of bacterial resistance. The compounds of the present invention when combined with β-lactam antibiotics will provide an effective treatment against life threatening bacterial infections. In accordance with the present invention there are provided compounds of general formula I or a pharmaceutically acceptable salt or in vivo hydrolyzable ester R5 thereof: wherein: One of A and B denotes hydrogen and the other an optionally substituted fused bicyclic heteroaryl group; and X═O or S.

BICYCLIC 6-ALKYLIDENE-PENEMS AS ?-LACTAMASES INHIBITORS

The present invention provides a compound of Formula (I), pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.