3074-42-8Relevant academic research and scientific papers
Nickel-catalysed selective N-arylation or N,N′-diarylation of secondary diamines
Brenner, Eric,Schneider, Rapha?l,Fort, Yves
, p. 6913 - 6924 (2002)
The selective synthesis of N-aryl or N,N′-diaryl piperazines and trimethylene(bis)piperidines from the corresponding diamines and aryl chlorides using a catalyst combination of Ni(0) associated to 2,2′-bipyridine is described. The Ni/2,2′-bipyridine catalyst is also effective for the sequential arylation of piperazine. The preparation of novel and unsymmetrical 1,4-diaryl piperazines is reported.
ARYLATION OF ALIPHATIC AMINES
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Page/Page column 27; 28; 30; 31, (2017/09/07)
The invention relates to a method for arylation of amines, such as aliphatic amines by reaction of aryl-halogens, e.g. chloro- or fluorobenzene derivatives without strongly electron withdrawing substituents in the presence of a strong base.
