30749-25-8

Upstream product

• 108-39-4 3-methyl-phenol 
• 75-26-3 isopropyl bromide 
• 42528-67-6 m-amino isobutyrophenone 
• 103323-37-1 1-(3-hydroxy-phenyl)-2-methyl-propan-1-one 
• 6301-50-4 3-isobutylcyclohex-2-en-1-one 

Downstream Products

• 89666-37-5 2-Hydroxy-2-(2-hydroxy-4-isobutyl-phenyl)-malonic acid diethyl ester 
• 148254-62-0 3-bromo-4,5-dimethylbenzyl 3-isobutylphenyl ether 
• 89666-12-6 2-Hydroxy-2-(2-hydroxy-4-isobutyl-phenyl)-propionic acid ethyl ester 
• 105401-92-1 (3-isobutyl-phenoxy)-acetic acid 

Relevant academic research and scientific papers

Preparation of diphenolics

A process for the production of diphenolic compounds having a divalent bridge. A first disubstituted phenol is reacted with an aldehyde in the presence of a secondary amine and excess alcohol to form an ether intermediate. The ether intermediate is reacted with a phenol having an open ortho or para position to form a diphenolic.

Preparation and Reactions of Dianions from the Cresols

With n-BuLi/KO-t-Bu, protons are removed from the hydroxyl and methyl groups of cresols 5 to give dianions 6 in yields of 85percent (ortho), 95percent (meta), and 42percent (para).These dianions react with alkyl halides, Me3SiCl, Bu3SnCl, CO2, and oxidizing agents at carbon only and with dialkyl sulfates at both carbon and oxygen.Thus phenol derivatives bearing primary alkyl groups can be prepared from the corresponding methylphenols via dianions 6.