42528-67-6Relevant academic research and scientific papers
Process for synthesizing m-isobutylaniline
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Paragraph 0011; 0012, (2018/04/01)
The invention relates to a process for synthesizing m-isobutylaniline. According to the invention, isobutyraldehyde and morpholine are used as starting materials and p-toluenesulfonic acid is used as a catalyst to synthesize 2-methyl-1-m-morpholinylpropylene; then 2-methyl-1-m-morpholinylpropylene and nitrobenzoyl chloride are subjected to condensation and hydrolysis, and then an aldehyde group is removed under the action of hydrochloric acid, so m-nitrophenylisobutyl ketone is synthesized; then m-aminophenylisobutyl ketone is synthesized through selective hydrogenation; and finally, m-isobutylaniline is synthesized through a Huang Minglong reaction.
Direct preparation of new organozinc reagents, aminophenylzinc iodides, and their applications
Jung, Hye-Soo,Kim, Seung-Hoi
, p. 1004 - 1006 (2015/02/19)
New organozinc reagents, 4-aminophenyl zinc iodide (A) and 3-aminophenyl zinc iodide (B), have been generated easily and effectively by the direct insertion of active zinc to iodoanilines which possess acidic protons. The subsequent coupling reactions of the organozincs with various acid chlorides turned out to be an efficient tool for the preparation of aminophenyl ketones.
Structure-based design of peptidomimetic ligands of the Grb2-SH2 domain
Schoepfer, Joseph,Gay, Brigitte,Caravatti, Giorgio,Garcia-Echeverria, Carlos,Fretz, Heinz,Rahuel, Joseph,Furet, Pascal
, p. 2865 - 2870 (2007/10/03)
We have designed and synthesized a (3-aminomethyl-phenyl)-urea scaffold to mimic the X+1-Asn part of the minimal phosphopeptide sequence, Ac-pTyr- X+1-Asn-NH2, recognized by the Grb2SH2 domain. The resulting compounds show the same d
