307520-98-5

Basic information

• Product Name: 3',4'-dibenzyloxy-7-hydroxy-flavone
• Synonyms: 3',4'-dibenzyloxy-7-hydroxy-flavone
• CAS NO: 307520-98-5
• Molecular Weight: 450.491
• Mol File: 307520-98-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3',4'-dibenzyloxy-7-hydroxy-flavone(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4'-dibenzyloxy-7-hydroxy-flavone(307520-98-5)
• EPA Substance Registry System: 3',4'-dibenzyloxy-7-hydroxy-flavone(307520-98-5)

Safety Data

• Hazardous Substances Data: 307520-98-5(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 3943-89-3 Ethyl protocatechuate 
• 307521-38-6 3-(3-chloropropoxy)-3',4'-dibenzyloxyflavone 
• 174398-83-5 ethyl 3,4-bis(benzyloxy)benzoate 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 883242-48-6 1-(3,4-bis-benzyloxy-phenyl)-3-(2,4-dihydroxy-phenyl)-propane-1,3-dione 

Downstream Products

• 307521-07-9 3',4'-dibenzyloxy-7-(hydroxyethoxy)flavone 
• 307521-05-7 3',4'-dibenzyloxy-7-methoxyflavone 
• 883242-55-5 3',4'-dibenzyloxy-7-(2,3-epoxypropoxy)flavone 
• 883242-80-6 7-(2-bromo-ethoxy)-3',4'-dibenzyloxy-flavone 
• 307521-10-4 3',4'-dibenzyloxy-7-(3-dimethylaminopropoxy)flavone 
• 30797-60-5 3’,4’-dihydroxy-7-methoxyisoflavone 
• 2150-11-0 3',4',7-trihydroxyflavone 
• 307521-34-2 7-(3-chloropropoxy)-3',4'-dibenzyloxyflavone 

Relevant articles and documents

Natural product-based design, synthesis and biological evaluation of 2′,3,4,4′-tetrahydrochalcone analogues as antivitiligo agents

A bioactive component, 2′,3,4,4′-tetrahydrochalcone (RY3-a) was first isolated from Vernohia anthelmintica (L.) willd seeds, and a set of its analogs, RY3-a-1–RY3-a-15 and RY3-c were designed and synthesized. Biological activity assays showed that RY3-c exhibited better melanogenesis and antioxidant activity and lower toxicity in comparison with RY3-a and butin. Further study tests showed that RY3-c exhibited better melanogenesis activity compared with the positive control 8-methoxypsoralan (8-MOP) in a vitiligo mouse model, suggesting that RY3-c is a good candidate antivitiligo agent. Mechanistic studies showed that RY3-c could repair cell damage induced by excessive oxidative stress and may exert melanin synthesis activity in the mouse melanoma B16F10 cell line by activating the mitogen-activated protein kinase (MAPK) pathway and the upregulation of c-kit.

OXY SUBSTITUTED FLAVONES AS ANTIHYPERGLYCEMIC AND ANTIDYSLIPIDEMIC AGENTS

The present invention provides novel substituted flavone derivatives which exhibit anti- hyperglycemic and antidyslipedemic activity. The invention also provides a method for controlling type ii diabetes and associated hyperlipidemic conditions in a mammal by administering compound of the present invention and compositions containing these derivatives.

Novel flavonoids

Novel flavonoids of formula (I) 1where A and E form together a C—C or C=C bond; R1, R2, R3, and R4 are H, OH, O(CH2)n— aromatic group, n=0-8; O(CH2)n N(CH3)q with n=0-8, q=0-3; O(CH2)n OH with n=1-8; O(CH2)n-halide with n=1-8; O(CH2)n COOH with n=0-8; O(CH2)n COOR′ with n=0-8 and R′ is C1-C8 alkyl or an aromatic group; O(CH2)n CONH R″ with n=0-8 and R″ is C1-C8 alkyl or an aromatic group, and sugars in mono-, di- or trimeric form or analogues thereof, with the proviso that R1 is not H, at least two of R2, R3 and R4 are H, and at most one of R1, R2, R3 and R4 is OH, are useful for the treatment of drug-induced toxicity, doxorubicin-induced cardiotoxicity, free radical mediated diseases, lung diseases, cancer, diabetes mellitus, cardiovascular disease, or arteriosclerosis.