883242-48-6

Basic information

• Product Name: 1-(3,4-bis-benzyloxy-phenyl)-3-(2,4-dihydroxy-phenyl)-propane-1,3-dione
• Synonyms: 1-(3,4-bis-benzyloxy-phenyl)-3-(2,4-dihydroxy-phenyl)-propane-1,3-dione
• CAS NO: 883242-48-6
• Molecular Weight: 468.506
• Mol File: 883242-48-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(3,4-bis-benzyloxy-phenyl)-3-(2,4-dihydroxy-phenyl)-propane-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-bis-benzyloxy-phenyl)-3-(2,4-dihydroxy-phenyl)-propane-1,3-dione(883242-48-6)
• EPA Substance Registry System: 1-(3,4-bis-benzyloxy-phenyl)-3-(2,4-dihydroxy-phenyl)-propane-1,3-dione(883242-48-6)

Safety Data

• Hazardous Substances Data: 883242-48-6(Hazardous Substances Data)

Upstream product

• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 174398-83-5 ethyl 3,4-bis(benzyloxy)benzoate 
• 100-39-0 benzyl bromide 
• 3943-89-3 Ethyl protocatechuate 

Downstream Products

• 883242-55-5 3',4'-dibenzyloxy-7-(2,3-epoxypropoxy)flavone 
• 307521-10-4 3',4'-dibenzyloxy-7-(3-dimethylaminopropoxy)flavone 
• 307521-34-2 7-(3-chloropropoxy)-3',4'-dibenzyloxyflavone 
• 307521-07-9 3',4'-dibenzyloxy-7-(hydroxyethoxy)flavone 
• 307521-05-7 3',4'-dibenzyloxy-7-methoxyflavone 
• 2150-11-0 3',4',7-trihydroxyflavone 
• 30797-60-5 3’,4’-dihydroxy-7-methoxyisoflavone 
• 307520-98-5 3',4'-dibenzyloxy-7-hydroxy-flavone 

Relevant articles and documents

Natural product-based design, synthesis and biological evaluation of 2′,3,4,4′-tetrahydrochalcone analogues as antivitiligo agents

A bioactive component, 2′,3,4,4′-tetrahydrochalcone (RY3-a) was first isolated from Vernohia anthelmintica (L.) willd seeds, and a set of its analogs, RY3-a-1–RY3-a-15 and RY3-c were designed and synthesized. Biological activity assays showed that RY3-c exhibited better melanogenesis and antioxidant activity and lower toxicity in comparison with RY3-a and butin. Further study tests showed that RY3-c exhibited better melanogenesis activity compared with the positive control 8-methoxypsoralan (8-MOP) in a vitiligo mouse model, suggesting that RY3-c is a good candidate antivitiligo agent. Mechanistic studies showed that RY3-c could repair cell damage induced by excessive oxidative stress and may exert melanin synthesis activity in the mouse melanoma B16F10 cell line by activating the mitogen-activated protein kinase (MAPK) pathway and the upregulation of c-kit.

OXY SUBSTITUTED FLAVONES AS ANTIHYPERGLYCEMIC AND ANTIDYSLIPIDEMIC AGENTS

The present invention provides novel substituted flavone derivatives which exhibit anti- hyperglycemic and antidyslipedemic activity. The invention also provides a method for controlling type ii diabetes and associated hyperlipidemic conditions in a mammal by administering compound of the present invention and compositions containing these derivatives.

Synthesis of novel 3,7-substituted-2-(3',4'-dihydroxyphenyl)flavones with improved antioxidant activity

A series of 3,7-disubstituted-2-(3',4'-dihydroxyphenyl)flavones was synthesized as potential cardioprotective agents in doxorubicin antitumor therapy. The influence of substituents on the 3 and 7 positions of the flavone nucleus on radical scavenging and