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307532-02-1

(S)-3-Amino-1-benzylpiperidine is a chiral chemical compound that belongs to the class of piperidines, characterized by a three-carbon chain attached to a piperidine ring. It is commonly used as a precursor in the synthesis of various pharmaceuticals and fine chemicals, particularly for the development of new drugs targeting central nervous system disorders and pain management. Its unique structure and properties make it a valuable building block for the synthesis of biologically active molecules. However, due to its potential toxicity and reactivity, (S)-3-Amino-1-benzylpiperidine should be handled and used with caution.

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  • 307532-02-1 Structure

  • Basic information

    1. Product Name: (S)-3-Amino-1-benzylpiperidine
    2. Synonyms: 1-BENZYL-PIPERIDIN-(S)-3-YLAMINE;AKOS 324;(3S)-1-(Phenylmethyl)-3-piperidinamine dihydrochloride;(S)-(+)-BENZYL-3-AMINOPIPERIDINE DIHYDROCHLORIDE;(S)-(+)-1-BENZYL-3-AMINOPIPERIDINE DIHYDROCHLORIDE;(S)-1-BENZYL-3-AMINOPIPERIDINE DIHYDROCHLORIDE;(S)-1-BENZYL-PIPERIDIN-3-YLAMINE;(S)-3-AMINO-N-BENZYLPIPERIDINE
    3. CAS NO:307532-02-1
    4. Molecular Formula: C12H18N2
    5. Molecular Weight: 190.28
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 307532-02-1.mol

  • Chemical Properties

    1. Melting Point: 237 °C (dec.)(lit.)
    2. Boiling Point: 281.2°C at 760 mmHg
    3. Flash Point: 113.9°C
    4. Appearance: /
    5. Density: 1.037g/cm3
    6. Vapor Pressure: 0.00363mmHg at 25°C
    7. Refractive Index: 1.56
    8. Storage Temp.: Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. CAS DataBase Reference: (S)-3-Amino-1-benzylpiperidine(CAS DataBase Reference)
    11. NIST Chemistry Reference: (S)-3-Amino-1-benzylpiperidine(307532-02-1)
    12. EPA Substance Registry System: (S)-3-Amino-1-benzylpiperidine(307532-02-1)

  • Safety Data

    1. Hazard Codes: Xi,T
    2. Statements: 36/37/38-25
    3. Safety Statements: 26-36-45-24/25
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 307532-02-1(Hazardous Substances Data)

307532-02-1 Usage

Uses

Used in Pharmaceutical Industry:
(S)-3-Amino-1-benzylpiperidine is used as a precursor in the synthesis of various pharmaceuticals for its potential applications in the development of new drugs, especially in the field of central nervous system disorders and pain management.
Used in Fine Chemicals Industry:
(S)-3-Amino-1-benzylpiperidine is used as a building block in the synthesis of various biologically active molecules, contributing to the creation of innovative compounds with potential therapeutic effects.
Used in Research and Development:
(S)-3-Amino-1-benzylpiperidine is utilized in research and development for further exploration of its potential applications and properties, as well as for the discovery of new drug candidates and chemical entities with therapeutic potential.

Check Digit Verification of cas no

The CAS Registry Mumber 307532-02-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,7,5,3 and 2 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 307532-02:
(8*3)+(7*0)+(6*7)+(5*5)+(4*3)+(3*2)+(2*0)+(1*2)=111
111 % 10 = 1
So 307532-02-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H18N2/c13-12-7-4-8-14(10-12)9-11-5-2-1-3-6-11/h1-3,5-6,12H,4,7-10,13H2/t12-/m0/s1

307532-02-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-3-Amino-1-benzylpiperidine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:307532-02-1 SDS

307532-02-1Downstream Products

307532-02-1Relevant articles and documents

Asymmetric michael additions of α-nitrocyclohexanone to aryl nitroalkenes catalyzed by natural amino acid-derived bifunctional thioureas

J?rres, Manuel,Schiffers, Ingo,Atodiresei, Iuliana,Bolm, Carsten

, p. 4518 - 4521 (2012/10/29)

A series of new thiourea catalysts prepared from natural amino acids have been applied in organocatalytic asymmetric Michael additions of α-nitrocyclohexanone to nitroalkenes. The resulting addition products are formed with excellent enantioselectivities (up to an er of 98:2) in good yields (up to 90%).

Synthesis of nitrosourea derivatives of pyridine and piperidine as potential anticancer agents.

Crider,Lamey,Floss,Cassady,Bradner

, p. 848 - 851 (2007/10/02)

Nitrosourea derivatives 18-22 which utilize either a piperidine or pyridine ring as a carrier group were synthesized and evaluated for anticancer activity. N'-(1-Benzyl-4-piperidinyl)-N-(2-chloroethyl)-N-nitosourea hydrogen maleate (19) exhibited good activity against intracranial L1210 leukemia as well as the mouse ependymoblastoma brain tumor system. Compound 19 exhibited comparable activity in the Lewis lung carcinoma system to N,N'-bis(2-chloroethyl)-N-nitrosourea. Replacement of the N-benzyl group in both the 3-piperidinyl- and 4-piperidinylnitrosoureas resulted in less active compounds in all tumor systems tested. The 3-pyridylnitrosourea 22 was inactive in the L-1210 leukemia system.

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